CURRICULUM VITAE
TERRY D. OBERLEY, MD, PhD
[Update: December 2005]
FORMAL EDUCATION AND POSITIONS HELD:
Education:
BS (Biology), from Northwestern University, Evanston, Illinois 1968
PhD (Microbiology) from Northwestern University, Evanston, Illinois 1973
Thesis Title: "The Effect of Streptolysin O on the Red Cell Membrane",
J.L. Duncan, PhD, Advisor
MD, from Northwestern University, Chicago, Illinois 1974
Postgraduate Education:
Intern in Pathology, University of Wisconsin Medical School 1974-75
USPHS Pathology Trainee, University of Wisconsin Medical School 1975-77
Resident in Pathology, University of Wisconsin Medical School 1977-78
American Cancer Society Fellow, Department of Pathology, University of Wisconsin 1977-78
Medical School
Board Certification:
American Board of Pathology (AP) 1978
Professional Appointments:
Assistant Professor, Department of Pathology, University of Wisconsin Medical School 1977-83
Associate Professor, Department of Pathology, University of Wisconsin Medical School 1983-91
Professor, Department of Pathology, University of Wisconsin Medical School 1991-present
Interim Chair, Dept. of Pathol. and Lab. Med., Univ. of Wis Medical School 1995
SPECIAL HONORS OR AWARDS:
Full academic scholarship to Northwestern University, 1964-68.
Full academic scholarship to Northwestern University Medical School, 1969
SOCIETY MEMBERSHIPS:
American Society of Investigative Pathology
American Society for Cancer Research
American Society of Nephrology
American Association for the Advancement of Science
American Society for Microbiology
American Society of Nephrology, Renal Pathology Society
Society for Free Radical Biology and Medicine
TEACHING:
Dr. Oberley has been involved in teaching medical students cell injury, renal pathology, and pathology laboratory for the past 30 years. Recently, his teaching has switched to mentoring of graduate students, postdoctoral fellows, residents, and faculty.
Classroom Teaching:
The following lectures were given in 2004-2005:
a. Pathology 703; 3 lectures
b. Renal Pathology, second year medical students, 2 lectures
c. Pathology 803, 2 lectures
d. Pathology Residents, one hour lecture on renal pathology
Mentor Teaching:
The following graduate students were trained in my laboratory:
a. Joanne Murphy-Ullrich, PhD. Dr. Murphy-Ullrich's PhD work resulted in ten refereed publications. In addition, Dr. Murphy-Ullrich and Dr. Oberley co-authored a chapter in a book (Fibronectin, edited by D.F. Mosher). She is currently an Associate Professor in the Department of Pathology at the University of Alabama at Birmingham.
b. Bruce Steinert, PhD. Dr. Steinert's PhD work resulted in five refereed publications. He is currently a Research Scientist in the Department of Surgery at Wayne State University.
c. An-Hang Yang, DDS, PhD. Dr. Yang's PhD work resulted in five refereed publications. He is currently Associate Professor of Pathology at the Medical School in Taipei, Taiwan.
d. Alfonso Gonzalez, MD, PhD. Dr. Gonzalez is currently in private clinical practice. His PhD work resulted in three refereed publications.
e. Janice Schultz, MS, PhD. Dr. Schultz’s work resulted in three published papers. She is currently raising a family.
f. Ning Li, MD, PhD. Dr. Li's work resulted in three refereed publications. She is currently a Scientist at UCLA Medical School.
g. Ted Zainal, MS, PhD. Dr. Zainal is an Assistant Professor, Dept. of Biochemistry, Winthrop College. His work resulted in four papers published.
h. Aekyong Kim, MS, PhD. is a postdoctoral fellow at Stanford University. Her work resulted in three published papers.
i. Luksana Chaiswing, MS, PhD. is working as a postdoctoral fellow in Dr. Oberley’s laboratory. Her PhD thesis work resulted in two publications as senior author and several publications as co-author.
j. Yafan Li, BS, PhD. graduated in December 2005. Her work resulted in one refereed publication with two other manuscripts submitted. She is currently looking for employment.
Other individuals trained in Dr. Oberley’s laboratory:
a. Shamila Mauyeddi, MD. Dr. Mauyeddi trained in kidney pathology in Dr. Oberley’s service. She is now Assistant Professor, Dept. of Pathology, University of Texas at Houston.
b. Andreas Friedl, MD. Dr. Friedl trained in kidney pathology in Dr. Oberley’s service. He is now Associate Professor, Dept. of Pathology, University of Wisconsin.
c. Weixiong Zhong, MD, PhD. Dr. Zhong served as a Research Fellow in Dr. Oberley’s laboratory. His work has resulted in multiple publications. Dr. Zhong also trained in kidney pathology with Dr. Oberley. He is now Assistant Professor, Dept. of Pathology, University of Wisconsin.
d. Jose Torrealba MD. Dr. Torrealba trained in kidney transplant pathology under Dr. Oberley’s supervision. His work has resulted in numerous publications, both as primary and co-author, with transplant faculty being senior authors and Dr. Oberley serving as co-author. Dr. torrealba is currently Assistant Professor, Dept of Pathology, University of Wisconsin.
d. Yung Yen Chiang, PhD. Dr. Chiang served as a postdoctoral fellow in Dr. Oberley’s laboratory. His work resulted in one publication.
e. Yi Xue, MD., PhD. Dr. Xue served as a postdoctoral fellow. His work resulted in two publications. He is now Instructor, Dept. of Neuroscience, Univ. of Tennessee Medical School.
f. Ying Zhang, PhD. served as a post-doctoral fellow in Dr. Oberley’s laboratory. Her work has resulted in one manuscript in preparation. She is currently raising a family.
g. Luksana Chaiswing, MS, Ph.D. is currently a post-doctoral fellow in Dr. Oberley’s laboratory.
h. Undergraduate students: Dr. Oberley has had many undergraduate students in his laboratory doing independent research. Ms. Jenny Ostrom received a Howard Hughes fellowship to attend any graduate program of her choice after working two years in his laboratory. Her work resulted in one publication. She received her Ph.D degree from the Department of Cellular and Molecular Biology, Washington University, St. Louis, MO.
i. High school students: Three minority students have received stipends from the Medical School for a summer research project in Dr. Oberley’s laboratory.
j. Current faculty mentoring: Dr. Oberley is currently mentoring Dr. Weixiong Zhong (has received NIH RO1 and VA Merit Review Awards), Dr. Jason Gee (has received VA Young Investigator Award with Dr. Oberley as mentor), and Dr. Ajit Djamali (has received an NIH R21 Award with Dr. Oberley as mentor).
PhD Thesis Committees in 2004
Deric Wheeler, Human Oncology (Ph.D. completed 5-2004)
Amit Dande, Pathology (M.S. degree completed 6-2004)
PhD Thesis Committees in 2005
Diantha Kelman, Environmental Toxicology
Sherly Briana Bellevue, Environmental Toxicology
Joseph Thomas Dever, Environmental Toxicology
Akua Oduro, Pathology; passed preliminary exam in November 2005.
Angela Gibson, MD/PhD student
Elyse Lee, Environmental Toxicology; Elyse graduated in December 2005.
Nadira DeAbrew, Environmental Toxicology
Yu Mu, Pathology
Marcus Calkins, Environmental Toxicology
W. Abdel Magid, Animal Sciences
Graduate Students in Dr. Oberley’s laboratory in 2005
Aekyong Kim, Environmental Toxicology; Aekyong graduated in December 2004 and remained in the lab through the end of February 2005
Jeanne Bourdeau-Heller, Pathology; Jeanne is scheduled to graduate in June 2006.
Yafan Li, Environmental Toxicology; Yafan graduated in December 2005.
Weihua Shan; Weihua worked in the summer learning techniques in Dr. Oberley', but in the fall of 2005 enrolled in the Environmental Toxicology program.
International Students in Dr. Oberley’s laboratory in 2005
Ramaneeya Nithipongvanitch; Ramaneeya is supported by a partial stipend from the government of Thailand to work on her Ph.D degree in Dr. Oberley’s laboratory.
Postdoctoral Fellow in Dr. Oberley’s laboratory in 2005
Dr. Luksana Chaiswing
International Fellow in Dr. Oberley’s laboratory in 2005
Dr. Cristiana Barbi received a followship from the Department of Pathology of the University of Bologna, Italy to pursue studies on redox and p53 in my laboratory. She began Sept 1, 2005.
Graduate student rotation in 2005
Rohinton Tarapore of Environmental Toxicology rotated through my lab in October 2005
Undergraduate students in 2005
Wade Alters (2 semesters of independent study)
David Gelbmann (research volunteer)
Resident Postgraduate Training:
Dr. Oberley has several major functions in training residents. These include supervision of pathology rotations
in kidney pathology and electron microscopy. He supervises residents in the interpretation of renal biopsies using light, immunfluorescence, and electron microscopy techniques. Residents are responsible for completing surgical pathology reports of selected cases after review with Dr. Oberley. In addition, once a week, cases from the files are reviewed to illustrate important diagnostic features of kidney pathology. Every other year, Dr. Oberley and one nephrology staff member (Dr. Moorthy), give a formal course in renal pathology for pathology residents and nephrology fellows.
The electron microscopy rotation is a unique opportunity for the residents; they are taught not only to interpret
pathology but are also encouraged to become adept at using the microscope. During the rotation, electron
microscopy cases are reviewed with the resident. Again, once a week, cases from the files are reviewed to
expand the diagnostic acumen of the trainees. Dr. Oberley presents several clinical conferences on electron
microscopy for pathology residents.
Dr. Oberley has served on the combined UW/VA Autopsy Service for two weeks, supervising residents in
gross dissection and subsequent interpretation of slides. Dr. Oberley performed this service until 2001, at which time the autopsy service was reorganized, now staffed by physicians specializing or especially interested in autopsy pathology. Dr. Oberley is available for examination of kidney autopsy slides and general electron microscopy of autopsy cases throughout the year.
Dr. Oberley encourages residents to do research in his laboratory. Dr. Ramesh Ramanathan, Dr. Alfonso
Gonzalez, Dr. Weixiong Zhong, and Dr. Jose Torrealba worked under his supervision; in each case, at least one research publication resulted.
Resident rotation in renal pathology in 2004-2005 under Dr. Oberley’s supervision:
Dr. Dong Chen
Dr. Brad Carmichael
Dr. Bob Corliss
Dr. Ching Voss
Dr. Sara Sewell
RESEARCH:
Dr. Oberley’s primary interest has been the role of oxygen radicals and antioxidant enzymes in both cell injury and carcinogenesis. He developed both tissue culture and in vivo techniques to study this problem. Dr. Oberley has made major contributions to this field of study. He has documented tissue and subcellular localization of antioxidant enzymes and oxidative damage products using well-characterized antibodies. He has demonstrated that human tumor cells have an imbalance of antioxidant enzymes. He has shown that both reactive oxygen species and antioxidant enzymes vary in specific ways in the mammalian cell cycle, suggesting a physiologic role for reactive oxygen species in the cell cycle, and a regulatory role for antioxidant enzymes during this process. His goal for the future is to use a variety of methodologies to establish a role for oxygen radicals in carcinogenesis and to document a role for antioxidant enzymes in regulation of cell cycle progression. Dr. Oberley’s research was described in a history of free radical research in the J. of NIH Research, 9:64-68, 1997, indicating his national recognition in this area. Dr. Oberley was invited to write a Commentary in the American Journal of Pathology; this overview article entitled “Oxidative damage and Cancer” appeared in the January 2002 issue ot this journal. Dr. Oberley was recently appointed for five years to the Editorial Board of Free Radical Biology and Medicine. Dr. Oberley ws named co-editor for a Forum in Antioxidant and Redox Signaling on “Redox State and Carcinogenesis.” He was recently appointed to the Editorial Board of the Biochemical Journal.
Because of his expertise in oxygen radicals, Dr. Oberley is a member of the Environmental Toxicology Program and has had three graduate students in this program. In addition, he is a member of the University of Wisconsin Comprehensive Cancer Center and was appointed to the Institute on Aging in 1997. In both 1997 and 2000, Dr. Oberley participated in completing a program project grant in molecular developmental toxicology and a successful grant application for a training program in aging.
PUBLICATIONS:
*Asterisk with italics indicates publications in which almost all work was completed in Dr. Terry Oberley’s laboratory and/or Dr. Terry Oberley is the primary or corresponding author. Dr. Oberley’s name is underlined in these primary publications.
Papers in Referreed Journals:
*1. Oberley TD, and Duncan JL: Characteristics of streptolysin O action. Infect Immun 4:683-687, 1971.
*2. Oberley TD, and Duncan JL: Streptolysin O induced alterations in rabbit erythrocyte membrane polypeptides. Biochem Biophys Res Comm 48:1339-1347, 1972.
3. Burkholder PM, Oberley TD, Barber TA, Beacom A, and Koehler C: Immune adherence in renal glomeruli: Complement receptor sites on glomerular capillary epithelial cells. Am J Path 86:635-654, 1977.
4. Barber TA, Oberley TD, and Burkholder PM: Application of correlative HVEM-SEM to the study of cultured renal glomerular cells. In: Scanning Electron Microscopy, IIT Research Institute, Chicago, Vol. II, 1977, pp. 595-602.
*5. Oberley TD, Burkholder PM, Barber TA, and Hwang CC: Cytochemical characterization of cultured adult guinea pig glomerular cells. Invest Cell Path 2:27-44, 1979.
*6. Oberley TD, Burkholder PM, and Mills MD: Culture of human glomerular cells. Am J Pathol 96:101-120, 1979.
*7. Oberley TD, Mosher DF, and Mills MD: Immunohistochemical localization of fibronectin within the renal glomerulus and its production by cultured glomerular cells. Am J Path 96:651-662, 1979.
8. Oberley LW, Oberley TD, and Buettner GR: The role of oxygen radicals and superoxide dismutases in cell differentiation, aging, and cancer. Medical Hypotheses 6:249-268, 1980.
*9. Oberley TD, Muth JV, and Murphy-Ullrich JE: Growth and maintenance of glomerular cells under defined conditions. Am J Path 101:43-51, 1980.
*10. Oberley TD, Murphy-Ullrich JE, and Muth JV: The effect of fetal calf serum on the biology of cultured glomerular cells. Diagnost Histopath 4:117-128, 1981.
11. Leuthauser SWHC, Oberley LW, Oberley TD, Sorenson JRJ, and Ramikrishna, K.: Antitumor effect of a copper coordination compound with superoxide dismutase-like activity. J Natl Cancer Inst 6:1077-1081, 1981.
*12. Oberley TD, Chung AE, Murphy-Ullrich JE, and Mosher DF: Studies on the localization of the glycoprotein GP-2 within the renal glomerulus in vivo and in cultured kidney cell strains in vitro. J Histochem Cytochem 29:1237-1242, 1981.
*13. Oberley TD, Gilbert EF, Arya S, and Viseskuhl C: Culture of human glomeruli from patients with metabolic and genetic diseases. Arch Path Lab Med 105:256-258, 1981.
14. Oberley LW, Oberley TD, and Buettner GR: Cell division in normal and transformed cells: The possible role of superoxide and hydrogen peroxide. Medical Hypotheses 7:21-42, 1981.
*15. Oberley TD, Murphy-Ullrich JE, and Muth JV: Morphologic and immunofluorescence studies on the effect of fibroblast growth factor on the culture of glomerular cell strains. Am J Path 102:129-237, 1981.
*16. Oberley TD, Murphy-Ullrich JE, and Muth JV: The growth of glomerular cells as a confluent monolayer: The effect of prostaglandins and extracellular matrix molecules. Am J Path 104:183-190, 1981.
17. Leuthauser SWC, Oberley LW, and Oberley TD: Anti-tumor activity of picolinic acid in CBA/J mice. Journal Natl Cancer Inst 68:123-126, 1982.
18. Mahler P, Oberley TD, and Yatvin M: Morphologic effects of protein restriction on the kidney following unilateral nephrectomy and radiation. Rad Res 89:546-58, 1982.
*19. Murphy-Ullrich JE, Oberley TD, and Mosher DF: Glomerular and vascular injury in mice following immunization with heterologous and autologous fibronectin. Virchows Archiv (Cell Path) 30:305-32l, 1982.
*20. Oberley TD, Murphy PJ, Steinert BW, and Albrecht RM: A morphologic and immunofluorescent analysis of primary guinea pig glomerular cell types grown in chemically defined media: Evidence for clonal growth and cell differentiation. Virchows Archiv (Cell Path) 41:145-170, 1982.
*21. Oberley TD, Murphy-Ullrich JE, Albrecht RM, and Mosher DF: The effect of the dimeric and multimeric forms of fibronectin on the adhesion and growth of primary glomerular cells. Exp Cell Res 145:265-276, 1983.
22. Glass N, Sires B, Oberley T, and Balish E: Is microbiologic flora a determinant of allograft rejection? An experimental study in gnotobiotic animals. J Surg Res 34:438-442, 1983.
23. Wilkey D, Yocum DE, Oberley TD, Karl L, and Sundstrom WR: Budd-Chiari Syndrome and renal failure in Bechet's: Report of a case and a review of the literature. Am J Med 75:541-550, 1983.
24. Zimmerman S, Dabbagh S, Oberley T, Friedman A, and Chesney R: Nephrotic syndrome in a three-year old boy. Am J Nephrol 3:286-292, 1983.
25. Sollinger HW, Starling JR, Oberley T, Glass NR, and Belzer FO: Severe "weeping" kidney after transplantation: A case report. Transplant Proc 15: 2157-160, 1983.
*26. Oberley TD, and Steinert BW: Effect of the extracellular matrix molecules fibronectin and laminin on the adhesion and growth of primary renal cortical epithelial cells. Virchows Archiv (Cell Path) 414:337-354, 1983.
27. Oberley LW, Rogers KL, Schutt L, Oberley TD, Leuthauser SWC, Sorenson JRJ: The role of glutathione in the antitumor effect of a copper-containing synthetic superoxide dismutase. Journal National Cancer Inst 71:1089-1094, 1983.
28. Friedman AL, Chesney RW, Oberley TD, and McEnery PT: Clinical systemic lupus erythematous with dense deposit disease. Internat J Ped Nephrol 4:171-175, 1983.
29. Sorenson JRJ, Oberley LW, Crouch RK, Kensler TW, Kishore V, Leuthauser SWC, Oberley TD, and Pezeshk, A.: Pharmacologic activities of copper compounds in chronic diseases. Biol Trace Element Research 5:257-273, 1983.
30. Oberley LW, Oberley TD: The role of superoxide dismutase and gene amplication in carcinogensis. J. Theoretical Biol 106:403-422, 1984.
31. Leuthauser SWC, Oberley LW, Oberley TD, and Loven DL: Lowered superoxide dismutase activity in distant organs of tumor-bearing mice. J Natl Cancer Inst 72:1065-74, 1984.
*32. Murphy-Ullrich JE, Oberley TD: Immune-mediated injury to basement membranes in mice immunized with murine laminin. Clin Immunol Immunopath 31:33-43, 1984.
*33. Murphy-Ullrich JE, Oberley TD, and Mosher DF: Detection of autoantibodies in rabbits immunized with denatured human fibronectin monomer. Am J Path 117:1-11, 1984.
34. Abreo K, Oberley TD, Gilbert EF, Opitz JM, and Updike S: Clinicopathologic Conference. A 29-year-old man with recurrent episodes of fever, abdominal pain and vomiting. Am J Med Genetics 18:249-264, 1984.
35. Yatvin MB, Oberley TD, and Mahler PA: The beneficial effect of dietary protein restriction on radiation nephropathy. Strahlentherapie 160:707-714, 1984.
*36. Oberley TD, Steinert BW, Yang AH, and Anderson PJ: Kidney glomerular explants in serum-free media: Sequential morphologic and quantitative analysis of cell outgrowths, Virchows Archiv (Cell Path.), 50:209-235, 1986.
*37. Oberley TD, Steinert BW, and Anderson PJ: Kidney glomerular explants in serum-free media: Role of individual medium components in cell outgrowth, Virchows Archiv (Cell Path.), 51:161-176, 1986.
*38. Steinert BW, Anderson PJ, Oberley LW, and Oberley TD: Kidney glomerular explants in serum-free media: Demonstration of intracellular antioxidant enzymes and active oxygen metabolites, In Vitro, 22:285-294, 1986.
39. Friedman AL, Langer, S., Oberley TD, Thornquist M: Alterations in rat renal glucose transport following in vivo use of Freund's adjuvant. Pediatr Res 20:443- 446, 1986.
*40. Oberley TD, Yang AH, and Gould-Kostka J: Selection of kidney cell types in primary glomerular explant outgrowths by in vitro culture conditions, J Cell Science 84:69-92, 1986.
*41. Murphy-Ullrich JE, Oberley TD, and Mosher DF: Serologic and pathologic studies of mice immunized with homologous fibronectin. Am J Path 125: 182-190, 1986.
42. Konick L, Hafez GR, Weiss SL, Oberley TD, Hartmann HA: Multiple myeloma with unusual intracranial manifestations. Arch Pathol Lab Med 110:755-756, 1986.
*43. Yang AH, Gould-Kostka J, Oberley TD: In vitro growth and differentiation of human kidney tubular cells on a basement membrane substrate. In Vitro 23:34-46, 1987.
44. Engstrand DW, England DE, Oberley TD: Microvillous ultrastructure in distinguishing between primary carcinoma of the lung and metastatic disease. Ultrastruct Pathol 11:53-58, 1987.
45. Oberley LW, Kasemset D, Autor AP, Oberley TD: Increase in manganese superoxide dismutase activity in the mouse heart after X-irradiation. Arch Bioch Biophys 254:69-80, 1987.
46. Reznikoff CA, Loretz LJ, Pesciotta DM, Oberley TD: Growth kinetics and differentiation in vitro of normal human uroepithelial cells in defined and serum-containing medium. J Cell Physiol 131:285-301, 1987.
47. Willson JKV, Bittner GN, Oberley TD, Meisner LF, and Weese JL: Human colon neoplastic cells in culture. Cancer Res 47:1-1, 1987.
48. Christian BJ, Loretz LJ, Oberley TD, and Reznikoff CA: Characterization of human uroepithelial cells immortalized in vitro by Simian Virus 40. Cancer Res, 47:6066-6073, 1987.
*49. Yang AH, Oberley TD, Oberley LW, Schmid SM, and Cummings KB: In vitro modulation of antioxidant enzymes in normal and malignant renal epithelium. In Vitro, 23:546-558, 1987.
50. Shorr RI, Longo WL, Oberley TD, Bozdech MJ, Walker DL: Cytomegalovirus associated tubulo-interstitial nephritis in an allogeneic bone marrow transplant recipient. Ann Int Med 107:51-52, 1987.
51. Kuebler JP, Oberley TD, Meisner LF, Sidky YA, Reznikoff CA, Borden EC, Cummings KB, Bogen GT: Effect of interferon alpha, interferon beta, and interferon gamma on the in vitro growth of human renal adenocarcinoma cells. Invest New Drugs 5:21-29, 1987.
52. Grauer GF, Culham CA, Cooley AJ, Poff BC, Oberley TD, Browfield MS, and Grieve RB: Clinicopathologic and histologic evaluation of Dirofilaria immitis-induced nephropathy in dogs. Am J Trop Med Hyg 37:588-596, 1987.
*53. Yang AH, Oberley TD, Oberley LW, Ramanathan R: Effect of cell substrate on antioxidant enzyme activities in cultured renal glomerular epithelium. Am J Path 130:616-628, 1988.
54. Pozniak MA, Kelcz F, Stratta RJ, Oberley TD: Extraneous factors affecting resistive index. Invest Radiol 23:899-904, 1988.
55. Oberley LW, Oberley TD: Role of antioxidant enzymes in cell immortalization and transformation. Mol Cell Biochem 84:147-153, 1988.
56. Grauer GR, Culham CA, Dubielzig RR, Presto SK, Oberley TD, Thomas CB, and Grieve RB: Effects of a specific thromboxane synthetase inhibitor on development of experimental Dirofilaria immitis immune complex glomerulonephritis in the dog. J Vet Int Med 2:192-200, 1988.
57. Bruyere HJ, Noonan JJ, Dong S, Oberley TD, Schmidt MJ, Gilbert EF, and Shug AL: The effects of caffeine on the ultrastructure and mitochondrial function of the embryonic chick heart. J Appl Toxicol 8:9-13, 1988.
58. Coursin DB, Cihla HP, and Oberley TD: Exacerbation of tallysomycin toxicity in rats by concurrent exposure to sublethal hyperoxia. Toxicology 55:225-237, 1989.
*59. Gonzalez A, Oberley TD, and Li JJ: Morphological and immunohistochemical studies on the estrogen-induced Syrian hamster renal tumor: Probable cell of origin. Canc Res 49:1020-1028, 1989.
*60. Oberley TD, Lauchner LJ, Pugh TD, Gonzalez A, Goldfarb S, Li SA, and Li JJ: Specific estrogen-induced cell proliferation of cultured Syrian hamster renal proximal tubular cells in serum-free chemically defined media. Proc Natl Acad Sci USA 86:2107-2111, 1989.
61. Wen SF, Friedman AL, and Oberley TD: Two case studies from a family with primary Fanconi syndrome. Amer J Kid Dis 13:240-246, 1989.
62. Oberley LW, Ridnour LA, Sierra-Rivera E, Oberley TD, and Guernsey DL: Superoxide dismutase activities of differentiating clones from an immortal cell line. J Cell Physiol 138:50-60, 1990.
63. Balish E, Filutowicz H, and Oberley TD: Correlates of cell-mediated immunity in Candida albicans-colonized gnotobiotic mice. Infect Immun 58:107-113, 1990.
64. Hopkins WJ, Reznikoff CA, Oberley TD, and Uehling DT: Adherence of uropathogenic E. coli. to differentiated human uroepithelial cells grown in vitro. J Urol 143:146-149, 1990.
*65. Oberley TD, Oberley LW, Slattery AF, Lauchner LJ, and Elwell JH: Immunohistochemical localization of antioxidant enzymes in adult Syrian hamster tissues and during kidney development. Am J Path 137:199-214, 1990.
66. Spitz DR, Elwell JH, Sun Y, Oberley LW, Oberley TD, Sullivan SJ, and Roberts RJ: Oxygen toxicity in control and H2O2-resistant Chinese hamster fibroblast cell lines. Arch Biochem Biophys 279:249-60, 1990.
*67. Oberley TD, Allen RG, Schultz, JL, and Lauchner LJ: Antioxidant enzymes and DES-induced proliferation of kidney tubular cells. Free Radic Biol and Med 10:79-83, 1991.
*68. Oberley TD, Gonzalez A, Lauchner LJ, and Li JJ: Characterization of early kidney lesions in estrogen-induced tumors in the Syrian hamster. Canc Res 51:1922-29, 1991.
69. McCormick ML, Oberley TD, Elwell JH, Oberley LW, Sun Y, and Li JJ: Superoxide dismutase and catalase levels during estrogen-induced renal tumorigenesis in the Syrian hamster. Carcinogenesis 12:977-83, 1991.
70. Chiang YY, Takebayashi S, Oberley TD: In vitro analysis of extracellular matrix production by porcine glomerular mesangial and vascular smooth muscle cells. Am J Pathol 138:1349-58, 1991.
71. Molteni KH, Oberley TD, Wolff JA, Friedman AL. Progressive renal insufficiency in methylmalonic acidemia. Pediatr Nephrol 5:323-26, 1991.
*72. Oberley TD, Oberley LW, Slattery AF, and Elwell JH: Immunohistochemical localization of glutathione-S-transferase and glutathione peroxidase in adult Syrian hamster tissues and during kidney development. Am J Path 139:355-69, 1991.
73. Schiller JH, Bittner G, Meisner LF, Oberley TD, Norback D, Schwabe M, Faltynek CR, Raab-Traub N: Establishment and characterization of an Epstein-Barr virus spontaneously transformed lymphocytic cell line derived from a hairy cell leukemia patient. Leukemia 5:399-407, 1991.
*74. Oberley TD, Slattery AF, Gonzalez A, Lauchner LJ, Li SA, and Li JJ: Comparative morphologic and immunohistochemical studies of estrogen plus alpha-napthoflavone-induced liver tumors in Syrian hamsters and rats. Am J Path 139:669-69, 1991.
75. St. Clair DK, Oberley TD, Ho YS: Overproduction of human MnSOD modulates paraquat-mediated toxicity in mammalian cells. FEBS Letters, 293:193-203, 1991.
76. Rago, R, Mitchen J, Cheng AL, Oberley T, Wilding G: Disruption of cellular energy balance by suramin in intact human prostate carcinoma cells, a likely antiproliferative mechanism. Cancer Res, 51:6629-35, 1991.
77. Deahl ST, Oberley LW, Oberley TD, Elwell JH: Immunohistochemical identification of superoxide dismutases, catalase, and glutathione-S-transferases in rat femurs. J Bone Mineral Res., 7:188-198, 1992.
78. Sullivan, SJ, Oberley TD, Roberts RJ, Spitz DR: A stable O2- resistant cell line: Role of lipid peroxidation byproducts in O2- mediated cell injury. Amer J Physiol 262: L748-L756, 1992.
79. St. Clair DK, Wan XS, Oberley TD, Muse KE, St. Clair WH: Overexpression of mitochondrial superoxide dismutase suppresses radiation-induced neoplastic transformation. Mol Carcinogen 6:238-242, 1992.
80. Wen SF, Parthasarathy R, Iliopoulos O, Oberley TD: Acute renal failure following binge drinking and nonsteroidal antiinflammatory drugs. Amer J Kid Dis 20:281-285, 1992.
81. Pozniak MA, Kelcz F, D'Alessandro A, Oberley TD, Stratta R: Sonography of renal transplants in dogs: The effect of acute tubular necrosis, cyclosporine nephrotoxicity, and acute rejection on resistive index and renal length. Amer J Radiol 158: 791-797, 1992.
82. Coursin DB, Cihla HP, Oberley TD, Oberley LW: Light and electron microscopic localization of antioxidant enzymes and isoenzymes of glutathione - S-transferase in normal rat lung. Amer J Physiol 263: L679-L691, 1992.
83. Schiller JH, Bittner G, Oberley TD, Kao C, Harris C, Meisner LF: Establishment and characterization of a SV-40 T-antigen immortalized human bronchial epithelial cell line. In Vitro Cell Devel Biol 28:461-464, 1992.
*84. Oberley TD, Coursin DB, Cihla HP, Oberley LW, El-Sayyad N, Ho YS: Immunolocalization of manganese superoxide dismutase in normal and transgenic mice expressing the human enzyme. Histochem J 25:267-279, 1993.
*85. Gonzalez A, Oberley TD, Schultz JL, Ostrom J, Li JJ: In vitro characterization of estrogen - induced Syrian hamster renal tumors: Comparison with an immortalized cell line derived from diethylstilbestrol - treated adult hamster kidney. In Vitro Cell Devel Biol 29A:562-573. 1993.
86. Sun Y, Oberley LW, Oberley TD, Elwell JH, Sierra-Rivera E: Lowered antioxidant enzymes in spontaneously transformed embryonic mouse liver cells in culture. Carcinogenesis, 14:1457-1463, 1993.
87. Kim ND, Oberley TD, Clifton KH: Primary culture of flow cytometry-sorted rat mammary epithelial cells (RMEC) subpopulations in a reconstituted basement membrane Matrigel. Exp Cell Res 209:6-20, 1993.
88. St. Clair DK, Oberley TD, Muse KE, St. Clair WH: Expression of manganese superoxide dismutase promotes cellular differentiation. Free Radic Biol Med 16:275-282, 1994.
*89. Oberley TD, Sempf JM, Oberley MJ, McCormick ML, Muse KE, Oberley LW: Immunogold analysis of antioxidant enzymes in human renal carcinoma. Virchows Archiv, 424:155-164, 1994.
*90. Oberley TD, Schultz JL, Oberley LW: In vitro modulation of antioxidant enzyme levels in normal hamster kidney and estrogen-induced hamster kidney tumor. Free Radic Biol Med 16:741-751, 1994.
*91. Muse KE, Oberley TD, Sempf JM, Oberley LW: Immunolocalization of antioxidant enzymes in adult hamster kidney. Histochem J 26:734-753, 1994.
92. Safford SE, Oberley TD, Urano M, St. Clair DK: Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. Cancer Res 54:4261-4265, 1994.
93. Hammond TG, Verroust PJ, Majewski RR, Muse KE, Oberley TD: Heavy endosomes isolated from the rat renal cortex show attributes of intermicrovillar clefts. Amer J Physiol 267:F516-F527, 1994.
94. Hammond TG, Majewski RR, Muse KE, Oberley TD, Morrissey LW: Energy transfer assays of rat renal cortical endosomal fusion: Evidence for superfusion. Amer J Physiol 267:F1021-F1033, 1994.
95. Moser R, Oberley TD, Daggett DA, Friedman AL, Johnson JA, Siegel FA: Effects of lead administration on developing rat kidney. I. Glutathione S-transferase isoenzymes. Toxicol and Applied Pharmacol 131:85-93, 1995.
*96. Oberley TD, Friedman AL, Moser R, Siegel FL: Effects of lead administration on developing rat kidney II. Functional, morphologic, and immunohistochemical studies. Toxicol and Applied Pharmacol 131:94-107, 1995.
*97. Oberley, TD, Schultz JL, Li N, Oberley LW: Antioxidant enzyme levels as a function of growth state in cell culture. Free Radical Biology and Medicine 19:53-65, 1995.
98. Li JJ, Oberley LW, St Clair DK, Ridnour LA, Oberley TD: Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene 10:1989-2000, 1995.
99. Urano M, Kuroda M, Reynolds R, Oberley TD, St. Clair DK,: Expression of manganese superoxide dismutase reduces tumor control radiation dose: Gene-radiotherapy. Cancer Research 55:2490-2493, 1995.
100. Li JJ, Li SA, Oberley TD, Parsons JA: Carcinogenic activities of various steroidal and nonsteroidal estrogens in hamster kidney: Relation to hormonal activity and cell proliferation. Cancer Research 55:4347-4351, 1995.
*101. Oberley TD, Sempf JM, Oberley LW: Immunohistochemical localization of antioxidant enzymes during hamster kidney development. Histochemical Journal 278:575-586, 1995.
*102. Oberley TD, Sempf JM, Oberley LW: Immunogold analysis of antioxidant enzymes in common renal tumors. Histology and Histopathology, 11:153-160, 1996.
*103. Coursin DB, Cihla HP, Sempf J, Oberley TD, Oberley LW: An immunohistochemical analysis of antioxidant and glutathione S-transferase enzyme levels in normal and neoplastic human lung. Histol Histopathol 11:851-860, 1996.
104. Zhong W, Oberley LW, Oberley TD, Domann FE, St. Clair DK: Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells. Cell Growth Differ 7:1175-1186, 1996.
105. Yen H-C, Oberley TD, Vichitbandha S, Ho Y-S, St. Clair DK: The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest 98:1253-1260, 1996.
106. Yoshida T, Watanabe M, Engelman DT, Engelman RM, Schley J, Maulik N, Ho Y-S, Oberley TD, Das DK: Transgenic mice overexpressing glutathione perioxidase are resistant to myocardial ischemia reperfusion injury. J Cell Mol Cardiol 28:1759-1767, 1996.
107. Chen C-W, Palangat M, Oberley TD, Roy D: Mechanism of antiproliferative activity of luteolin against stilbene-estrogen stimulation of hamster renal epithelial cells. Int J Oncol 9:811-814, 1996.
108. Mitchen J, Oberley TD, Wilding G: Extended culturing of androgen responsive human primary epithelial prostate cell isolates by continuous treatment with interstitial collagenase. Prostate 30:7-19, 1997.
109. Chen C-W, Oberley TD, Roy D: Inhibition of stilbene estrogen-induced cell proliferation of renal epithelial cells through the modulation of insulin-like growth factor-1 receptor expression. Cancer Lett 105:51-59, 1996.
110. Zhong W, Oberley LW, Oberley TD, St Clair DK: Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene 14:481-490, 1997.
111. Suzuki K, Oberley TD, Pugh TD, Sempf JM, Weindruch R: Caloric restriction diminishes the age-associated loss of immunoreactive catalase in rat prostate. Prostate 33:256-263, 1997.
*112. Oberley TD, Oberley LW: Antioxidant enzymes and cancer. Histol Histopathol 12:525-535, 1997.
113. Liu R, Oberley TD, Oberley LW: Transfection and expression of MnSOD cDNA decreases tumor malignancy of human oral squamous carcinoma SCC-25 cells. Human Gene Therapy 8:585-595, 1997.
114. Armstrong N, Buckley P, Oberley T, Fechner Jr. J, Dong Y, Hong X, Kirk A. Neville Jr.D, Knechtle S. Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9. Transplantation 66: 5-13, 1998.
115. Browne KE, Kinter MT, Oberley TD, Freeman ML, Frierson HF, Ridnour LA, Tao Y, Oberley LW, Spitz DR: Stimulation of gammaglutamyl transpeptidase gene expression and oxidative damage in an animal model of hemochromatosis: A potential adaptive response. Free Radical Biol Med 24:545-555, 1998.
116. Knechtle SJ, Fechner JJ, Dong Y, Stavrou S, Neville Jr.DM, Oberley T, Buckley P, Armstrong N, Rusterholz K, Hong X, Tsuchida M, Hamawy MM.. Primate renal transplants using immunotoxin. Surgery 124: 438-446, 1998.
*117. Li N, Oberley TD, Oberley LW, Zhong W: Overexpression of manganese superoxide dismutase in DU 145 human prostate carcinoma cells has multiple effects on cell phenotype. The Prostate 35:221-233, 1998.
*118. Li N, Oberley TD, Oberley LW, Zhong W: Inhibition of cell growth in NIH3T3 fibroblasts by overexpression of manganese superoxide dismutase: Mechanistic studies. J. Cell. Physiol. 175;359-367, 1998.
119. Liu R, Oberley TD, Oberley LW: The effects of expression of nitric oxide synthetase gene on tumor biology of human oral carcinoma SCC-25 cells. Cell Growth and Diff. 9:239-246, 1998.
120. Majima H, Oberley TD, Furukama K, Mattson MP, Yen H-C, St. Clair DK: Prevention of mitochondrial injury by manganese superoxide dismutase: A primary mechanism for alkaline-induced cell death. J. Biol. Chem 273:8217-8224, 1998.
121. Daggett DA, Oberley TD, Nelson SA, Wright LS, Kornguth SE, Siegel FL: Effects of lead in rat kidney and liver: GST overexpression and oxidative stress, Toxicology, 128:191-206, 1998.
*122. Li N, Oberley TD: Modulation of antioxidant enzymes, reactive oxygen species, and glutathione levels in manganese superoxide dismutase-overexpressing NIH/3T3 fibroblasts during the cell cycle. J Cell Physiol 177: 148-160, 1998.
123. Wright LS, Kornguth SE, Oberley TD, Siegel FL: Effects of lead on glutathione s-transferase expression in rat kidney: A dose-response study. Toxicol Sciences, 46:254-259, 1998.
124. Klivenyl P, St. Clair D, Wermer M, Yen H-C, Oberley T, Yang L, Beal MF: Manganese superoxide dismutase overexpression attenuates MPTP Toxicity, Neurobiology of Dis, 5:253-258, 1998
125. Yen H-C, Oberley TD, Gairola CG, Szweda LI, St. Clair DK. Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice. Arch Biochem Biophys 362: 59-66, 1999.
126. Thongphasuk J, Oberley L.W, Oberley TD, Martin SM. Induction of superoxide dismutase and cytotoxicity by manganese in human breast cancer cells. Arch Biochem Biophys 365: 317-327, 1999.
*127. Zainal TA, Weindruch R, Szweda LI, Oberley TD. Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload. Free Radic Biol Med 26: 1181-1193, 1999.
128. Pugh TD, Oberley TD, Weindruch R. Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res 59: 1642-1648 1999.
*129. Li N, Zhai Y, Oberley TD. Two distinct mechanisms for inhibition of cell growth in human prostate carcinoma cells with antioxidant enzyme imbalance. Free Radic Biol Med 26: 1154-1568, 1999.
130. Hall DM, Baumgardner KR, Oberley TD, Gisolfi CV. Splanchnic tissues undergo hypoxic stress during whole body hyperthermia. Am J Physiol 276: G1195-G1203, 1999.
131. Ripple MO, Hagopian K, Oberley TD, Schatten H, Weindruch R. Androgen-induced oxidative stress in human LNCAP prostate cancer cells is associated with mitochondrial modifications. Antioxidants and Redox Signaling 1: 71-81, 1999.
*132. Oberley TD, Toyokuni S, Szweda L. Localization of hydroxynonenal protein adducts in normal human kidney and selected human kidney cancers. Free Radic Biol Med 27: 695-703,1999.
133. Kiningham KK, Oberley TD, Lin S-M, Mattingly CA, St. Clair DK. Overexpression of manganese superoxide dismutase (MnSOD) protects against mitochondrial-initiated poly (ADP-ribose) polymerase-mediated cell death. FASEB J 13: 1601-1610, 1999.
134. Wenk J, Brennelsen P, Wlaschek M, Poswig A, Bririba K, Oberley T, Scharffetter-Kochanek K. Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the AP-1 mediated induction of matrix-metalloprotease-1 (MMP-1). J Biol Chem 274: 25869-25876, 1999.
135. Kim ND, Oberley TD, Yasukawa-Barnes J, Clifton KH. Persistence of stem-like cells in clonal glandular structures in mammary cell grafts. Exp. Cell Res 260:146-159, 2000.
136. Lam EWN, Hammad HM, Zwacka R, Darby CJ, Baumgardner KR, Davidson BL, Oberley TD, Engelhardt JJ, Oberley LW. Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumors. J Dent. Res 79:1410-1717, 2000.
137. Lagoo A, Buckley PJ, Burchell LJ, Fechner J, Tsuchida M, Dong Y, Hong X, Brunner K, Oberley TD, Knechtle S. Increased glomerular deposits of von Willenbrand factor in chronic, but not acute, rejection of primate renal allografts. Transplantation 70:877-886, 2000.
138. Chen Z, Oberley TD, Ho Y-H, Chua CC, Siu B, Hamdy RC, Epstein C.J, Chua BL. Overexpression of CuZnSOD in coronary endothelium attenuates myocardial ischemia/reperfusion injury. Free Rad Biol Med 29:589-596, 2000.
139. Reddig PJ, Dreckschmidt NE, Ahrens H, Simsiman R, Tseng C.-P, Zou J, Oberley T.D, Verma AK. Transgenic mice overexpressing protein kinase Cδ in the epidermis are resistant to skin tumor promotion by 12-0-tetradecanoyl-13-acetate. Cancer Research 59: 5710-5718, 1999.
140. Hall DM, Oberley TD, Moseley PM, Oberley LW, Weindruch R, Kregel KC. Caloric restriction improves thermotolerance and reduces hyperthermia-induced cellular damage in old rats. FASEB J 14: 78-86, 2000.
141. Zhang HJ, Yan T, Oberley TD, Oberley LW. Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype. Cancer Res 59: 6276-6283, 1999.
142. Hall DM, Xu L, Drake V, Oberley LW, Oberley TD, Moseley PL, Kregel KC. Aging reduces adaptive capacity and stress protein expression in the liver after heat stress. J Applied Physiol 89: 749-759, 2000.
143. Reddig PJ, Dreckschmidt, NE, Zou J, Bourguignon SE, Oberley TD, Verma AK. Transgenic mice overexpressing protein kinase Cε in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. Cancer Res. 60: 595-602, 2000.
*144. Zainal TA, Oberley TD, Allison DB, Szweda L.I, Weindruch R. Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J 14: 1825-1836, 2000.
*145. Oberley TD, Zhong W, Szweda LI, Oberley LW. Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium. Prostate 44: 144-155, 2000.
*146. Oberley TD, Zainal TA. Morphologic assessment of oxidative damage: a review. Age 23:17-24, 2000.
147. Becker BN, Jacobson LM, Becker YT, Radke NA, Heisey DM, Oberley TD, Pirsch JD, Sollinger HW, Brazy PC, Kirk AD. Renin-angiotensin system gene expression in post-transplant hypertension predicts allograft function. Transplantation 69: 1485-1491, 2000.
148. Kusaka S, Grailer AP, Fechner Jr JH, Jankowska-Gan E, Oberley T, Sollinger HW, Burlingham, WJ. Clonotype analysis of human alloreactive T cells: a novel approach to studying peripheral tolerance in a transplant recipient. J Immunol. 164: 2240-2247, 2000.
149. Burlingham W, Kusaka S, Chin L, Hullett D, Knechtle S, Sollinger H, Oberley T, Pirsch J, Kirk A, Becker B. Focal infiltrates in kidney allografts: Developing a model for clinical transplant peripheral tolerance. Graft 2: 253-260, 1999.
150. Li S, Yan T, Yang J-Q, Oberley TD, Oberley LW. The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res 60: 3927-3939, 2000.
151. Bostwick D, Alexander E, Singh R, Shan A, Qian J, Santella R, Oberley LW, Yan T, Zhong W, Jiang X, Oberley TD. Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer. Cancer 89: 123-134, 2000.
*152. Oberley TD, Verwiebe E, Zhong W, Kang S.W, Rhee SG. Localization of the thioredoxin system in normal rat kidney. Free Radic Biol Med 30: 412-424 2001.
153. Jansen AP, Verwiebe EG, Dreckschmidt NE, Wheeler DL, Oberley TD, Verma AK. Protein kinase Ce transgenic mice: New model for metastatic squamous cell carcinoma. Cancer Res 61:808-812, 2001.
154. De Las Casas LE, Hoerl HD, Oberley TD, Hafez GH, Sempf JM, Shalkham J.E, Kurtycz DFI. Myoepithelioma presenting as a midline cystic tongue lesion: Cytology, histology, ancillary studies, and differential diagnosis. Diag Cytopathol 24: 403-407, 2001.
155. Jansen AP, Dreckschmidt NE, Verwiebe EG, Wheeler DL, Oberley TD, Verma AK. Induction of epidermal ODC and hyperplasia during skin tumor promotion of PKCa, -d, and -e transgenic mice. Int J Cancer 93: 635-643, 2001.
156. Zhao Y, Xue Y, Oberley TD, Kiningham KK, Lin S, St. Clair D. Overexpression of MnSOD suppresses tumor formation by modulation of AP-1 signaling in a multistage skin carcinogenesis model. Cancer Res 61: 6082-6088, 2001.
*157. Zhong W, Oberley TD, Rhee SG. Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cell line. Cancer Res 61: 6082-6088, 2001.
158. Becker BN, Jacobsen LM, Hullett DA, Radke NA, Oberley TD, Brazy PC, Kirk AD. Angiotensin II receptor expression in human renal allografts: an association with chronic allograft nephropathy. Clin Nephrol 56: 1-8, 2001.
159. Raineri I, Carlson EJ, Gacayan R, Carra S, Oberley TD, Huang T-T, Epstein CJ. High-level expression of a transgene for manganese superoxide dismutase is associated with decreased fertility and growth retardation. Free Radic Biol Med 31: 1018-1030, 2001.
160. Fechner JH, Dong Y, Hong XN, Brunner KG, Tsuchida M, Neville D, Scharff J, Lee F, Oberley TD, Peters D, Schultz JM, Manthei ER, Hamawy MM, Knechtle SJ. Graft survival in a rhesus transplant model after immunotoxin-mediated T-cell depletion is enhanced by mycophenolate and steroids. Transplantation 72 (4): 581-587, 2001.
161. Cho CS, Burkly LC, Fechner JH, Kirk AD, Oberley TD, Dong Y, Brunner KG, Peters D, Tenhoor CN, Nadeau K, Yagci G, Ishido N, Schultz JM, Tsuchida M, Hamawy MM, Knechtle SJ. Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients. Transplantation 72(4):587-597, 2001.
162. De Las Casas LE, Hoerl HD, Bardales RH, Pirsch JD, Sempf JM, Wetzel DJ, Stewart J, Oberley TD, Kurtycz DFI. Utility of urinary cytology for diagnosing human polyoma virus infection in transplant recipients: A study of 37 cases with electron microscopic analysis. Diagn Cytopathol 25: 376-381, 2001.
*163. Oberley TD. Oxidative damage and cancer. Amer J Path 160: 403-408, 2002.
164. Lin T-M, Ko K, Moore RW, Simanainen U, Oberley TD, Peterson RE. Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice. Toxicol Sci 68 (2): 479-487, 2002.
165. Zhao Y, Oberley TD, Chaiswing L, Lin, S-M, Epstein CJ, Huang T-T, St. Clair D. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene 21: 3836-3846, 2002.
166. Miller FJ, Sharp WJ, Fang X, Oberley LW, Oberley TD, Weintraub NL. Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling. Arterioscler Thromb Vasc Biol 22 (4): 560-565, 2002.
167. Fernandez LA, Torrealba J, Yagci G, Ishido N, Tsuchida M, Kim H, Dong Y, Oberley T, Fechner J, Colburn MJ, Schultz J, Kanmaz T, Hu H, Knechtle SJ, Hamawy MM. Piceatannol in combination with low doses of cyclosporin A prolongs kidney allograft survival in a stringent rat transplant model. Transplantation 74: 1609-1617, 2002.
168. Yang J, Lam EWN, Hammad HM, Oberley TD, Oberley LW. Antioxidant enzyme levels in oral squamous cell carcinoma and normal human oral epithelium. J Oral Pathol Med 31: 71-77, 2002.
169. Li N, Wang M, Oberley TD, Sempf J, Nel AE. Comparison of the pro-oxidative and pro-inflammatory effects of organic DEP chemicals in bronchial epithelial cells and macrophages, J Immunology 169: 4531-4541, 2002.
170. Elegbede JA, Hayes K, Schell K, Oberley TD, Verma AK. Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid. Life Sci 71 (4): 421-436, 2002.
171. Wheeler D.L, Ness KJ, Dreckschmidt NE, Oberley TD, Verma AK. Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C e transgenic mice by a-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. Cancer Res 63: 3037-3042, 2003.
172. Li N, Sioutas C, Cho A, Schmitz, D, Misra C, Sempf J, Oberley T, Froines J, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111: 455-460, 2003.
173. Plymate SR, Haugk, KH, Sprenger CC, Nelson PS, Tennant MK, Zhang Y, Oberley LW, Drivdahl R, Oberley TD. Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding protein-related protein 1. Oncogene 22: 1024-1034, 2003.
174. Kahan BW, Jacobsen LM, Hullett DA, Ochoada J, Oberley TD, Lang K, Odorico JS: Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation. Diabetes 52:2016-2024, 2003.
175. Szweda PA, Camouse M, Lundberg KC, Oberley TD, Szweda LI: Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems. Ageing Res Rev 2: 383-405, 2003.
176. Wheeler DL, Ness KJ, Oberley TD, Verma AK: Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice. Cancer Res 63: 6547-6555, 2003.
177. Torrealba JR, Fernandez LA, Kanmaz T, Oberley TD, Schultz JM, Brunner KG, Peters D, Fechner Jr. JH, Dong
Y, Hu H, Hamawy MM, Knechtle SJ. Immunotoxin-treated rhesus monkeys: a model for renal allograft chronic rejection. Transplantation 76: 524-530, 2003.
178. Torrealba JR, Colburn M, Golner S, Chang Z, Scheunemann T, Fechner J, Roenneburg D, Hu H, Alam T, Kim HT, Kanmaz T, Oberley T, Knechtle S, Hamawy H. Selenium binding protein-1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy. In press, Amer J Transplant, 2004.
179. Torrealba J, Katayama M, Fechner J, Jankowska-Gan E, Kusaka S, Xu Q, Schultz J, Oberley T, Hu H, Hamawy M, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham W, Knechtle S. Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-β1+CD4+. T regulatory cell infiltrates. J. Immunology 172: 5753-5764, 2004.
180. Kanmaz T, Fechner J, Torrealba J, Kim H, Dong Y, Oberley T, Schultz J, Bloom D, Katayama M, Dar W, Markovits J, Schuler W, Hu H, Hamawy M, Knechtle S. Monotherapy with the anovel human anti-CD154 monoclonal antibody AB1793 in rhesus monkey renal transplantation model. Transplantation 77: 914-920, 2004.
*181. Oberley TD, Xue Y, Zhao Y, Kiningham K, Szweda LI, St. Clair DK: In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model. Antiox & Redox Signaling 6: 537-548, 2004.
*182. Kim A, Zhong W, Oberley TD: Reversible modulation of cell cycle kinetics in NIH/3T3 mouse fibroblasts by inducible overexpression of mitochondrial manganese superoxide dismutase. Antiox & Redox Signaling 6: 489-500, 2004.
*183. Oberley TD: Mitochondria, manganese superoxide dismutase, and cancer. Antiox & Redox Signaling 6: 483-487, 2004.
184. Zhong W, Yan T, Webber MM, Oberley TD: Alteration of cellular phenotype and responses to oxidative stress by manganese superoxide dismutase and a superoxide dismutase mimic in RWPE-2 human prostate adenocarcinoma cells. Antiox & Redox Signaling 6: 513-522, 2004.
185. Ridnour LA, Oberley TD, Oberley LW: Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal. Antiox & Redox Signaling 6: 501-511, 2004.
*186. Chaiswing L, Cole MP, St. Clair DK, Ittarat W, Szweda LI, Oberley TD: Oxidative damage precedes nitrative damage in Adriamycin-induced cardiac mitochondrial injury. Toxicologic Pathology 32:1-12, 2004.
187. Zhang HJ, Doctrow SR, Xu L, Oberley LW, Beecher B, Morrison J, Oberley TD, Kregel KC. Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress. The FASEB Journal 10.1096/fj.04-1629fje. Published online August 19, 2004. The FASEB J 18: 1547-1549, 2004.
188. Fernandez LA, Tsuchida M, Manthei E, Fechner Jr. JH, Oberley TD, Leverson GE, Knechtle SJ, Hamawy MM. Immune status assay (ISA): a noninvasive procedure for studying allograft rejection. Transplant Immunology 13: 147-154, 2004.
189. Wheeler DL, Reddig PJ, Ness KJ, Leith CP, Oberley TD, Verma AK. Overexpression of protein kinase C-e in the mouse epidermis leads to a spontaneous myeloproliferative-like disease. Amer J Pathol 166: 117-126, 2005.
*190. Kim A, Murphy MP, Oberley TD. Mitochondrial redox state regulates transcription of the nuclear-encoded mitochondrial protein manganese superoxide dismutase: a proposed adaptive response to mitochondrial redox imbalance. Free Radic Biol Med 38: 644-654, 2005.
191. Elchuri S, Oberley TD, Qi W, Eisenstein RS, Roberts LJ, Van Remmen H, Epstein CJ, Huang T-T. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 24: 367-380, 2005.
*192. Chaiswing L, Cole MP, Ittarat W, Szweda LI, St. Clair DK, Oberley TD. Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in adriamycin-induced mitochondrial toxicity. Molecular Cancer Therapeutics 4(7): 1-9, 2005.
193. Zhao Y, Chaiswing L, Oberley TD, Batinic-Haberle I, St. Clair W, Epstein CJ, St. Clair D. A mechanism-based approach for the reduction of skin carcinogenesis. Cancer Res 65 (4): 1401-1405, 2005
194. Djamali A, Reese S, Yracheta J, Oberley T, Hullett D, Becker B. Epithelial-to-mesenchymal transition and oxidative stress in chronic allograft nephropathy. Amer J Transplantation 5 (3): 500-509, 2005.
195. Djamali A, Reese S, Oberley T, Hullett D, Becker B. Heat shock protein 27 in chronic allograft nephropathy: a local stress response. Transplantation 79 (12): 1645-1657, 2005
196. Zhao Y, Chaiswing L, Oberley TD, Colburn N, St. Clair DK. P53 translocation to mitochondria precedes its nuclear migration and targets mitochondrial oxidative defense protein-mitochondrial manganese superoxide dismutase. Cancer Res 69: 3745-3750, 2005.
197. St. Clair DK, Zhao Y, Chaiswing L, Oberley TD. Modulation of skin carcinogenesis by SOD. Biomedicine & Pharmacotherapy 59: 209-214, 2005.
*198. Kim A, Oberley LW, Oberley TD. Induction of apoptosis by adenovirus-mediated manganese superoxide dismutase overexpression in SV-40 transformed human fibroblasts. Free Radic Biol Med 39: 1128-1141, 2005.
*199. Li Y, Wheeler DL, Alters W, Chaiswing L, Verma AK, Oberley TD. Epidermal destruction and subsequent epidermal hyperplasia are key features of the papilloma-independent squamous cell carcinoma phenotype in PKCe overexpressing transgenic mice. Toxicologic Path 33: 1-11, 2005.
200. Cole MP, Chaiswing L, Oberley TD, Edelmann SE, Plsascik MT, Lin S-M, Kiningham KK, St Clair DK. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. In press, Cardiovascular Research, 2005.
201. Lien Y-C, Lin S-M, Nithipongvanitch R, Oberley TD, Noel T, Zhao Q, Daosukho C, St. Clair D. TNF receptors deficiency exacerbated Adriamycin-induced cardiomyocyte apoptosis: an insight into the Fas connection. In press, Mol Cancer Therap, 2005.
202. Zhao Y, Wang L-M, Yen H-C, Chaiswing L, Oberley TD, Lien Y-C, Lin S-M, Mattson, St. Clair D. Tamoxifen protects against acute TNFalpha-induced cardiac injury via improving mitochondrial functions. In press, Free Radic Biol Med, 2005.
Papers Submitted to Refereed Journals But Not Yet Accepted:
1. Baba F, Zhong W, Becker B, Oberley T. Monoclonal light chain deposition disease in the kidney and liver secondary to multiple myeloma: a case report. Submitted, Nephron, 2005.
*2. Bourdeau-Heller J, Oberley TD. A metabolic network in DU145 prostate carcinoma cells within and between oxygen niches. Submitted, The Prostate, 2005.
*3. Li Y, Wheeler DL, Nithipongvanitch R, Verma AK, Oberley TD. Mechanistic insights into the papilloma-independent squamous cell carcinoma phenotype observed in transgenic mice overexpressing protein kinase C epsilon in a skin chemical carcinogenesis model. Submitted, Cancer Research, 2005.
*4. Li Y, Shan W, Nithipongvanitch R, Verma AK, Oberley TD. Distinct biochemical and biologic effects of 12-O-tetradecanoylphorbol-13-acetate dependent on keratinocyte differentiation and PKC epsilon levels. Submitted, Oncogene, 2005.
5. Josson S, St. Clair DK, Xu Y, Fang F, Oberley TD, St. Clair WH. Inhibition of RelB suppresses the tumorigenicity of androgen independent prostate cancer. Submitted, Oncogene, 2005.
Chapters in Books:
1. Barber TA, Oberley TD, Burkholder PM: Application of correlative HVEM-SEM to the study of cultured renal glomerular cells. In: Scanning Electron Microscopy, Vol. II, ITT Research Institute, Chicago, 1977, pp. 595-602.
2. Oberley LW, Leuthauser SWHC, Buettner GR, Sorenson JRJ, Oberley TD and Bize IB: The use of superoxide dismutase in the treatment of cancer. In: Active Oxygen and Medicine, A. Autor, Raven Press, 1981.
3. Leuthauser SWC, Oberley LW, Oberley TD, Sorenson JRJ and Buettner GR: Antitumor activity of a copper chelate which has superoxide dismutase activity and an iron chelater. In: Oxygen and Oxy Radicals in Chemistry and Biology, Ed. L Powers and W Rodgers, Academic Press, 1981.
*4. Oberley TD and Burkholder PM: Culture of human glomerular cells. In: Immunologic Mechanisms in Renal Disease, eds. N.B. Cummings and A.F. Michael, Plenum Press, 1982.
5. Oberley LW, Leuthauser SWC, Oberley TD, Sorenson JRJ, and Pasternak RF: Antitumor activities of compounds with superoxide dismutase activity. In: Biological Trace Element Research, ed. JRJ Sorenson, Humana Press Inc., Clifton, NJ, 1982.
6. Oberley LW, Schrieber AE, Rogers KL, Schutt L, Loven DP, Oberley TD and Pasternak RF: Antitumor therapies based on inhibition of antioxidant enzymes. In: Third International Conference on Superoxide and Superoxide Dismutases, Elsevier Press, New York, 1983.
*7. Oberley TD: Possible role of reactive oxygen metabolites in cell division. In: Superoxide Dismutases: Role in Pathologic States. LW Oberley, Ed., CRC Press, 1985.
8. Oberley LW, and Oberley TD: Free radicals, cancer and aging. In: Free Radicals, Aging and Degenerative Diseases, JE Johnson, Ed, Alan R. Liss, 1986.
9. Higgy NA, Verma AK, Erturk E, Oberley TD, El-Aaser AA, El-Merzabani MM, and Bryan GT: Escherichia coli infection of the urinary bladder: Induction of tumors in rats receiving nitrosamine precursors and augmentation of bladder carcinogenesis by N-nitrosobutyl (4-Hydroxybutyl) amine. In: Relevance of N-Nitroso compounds to human cancer: exposures and mechanisms, IARC, H. Bartsch, IK O'Neill, and R Schulte-Hermann, Eds, World Health Organization, pp. 380-383, 1987.
10. Li JJ, Li SA, Oberley TD, Haaf H, Goldfarb S, and Pugh TD: Estrogen carcinogenicity: Hormonal, morphologic, and chemical interactions. In: Chemical Carcinogens. Activation Mechanisms, Structural and Electronic Factors, and Reactivity. PA Politzer, L Roberts, Eds, Elsevier Science Publishers, Amsterdam, The Netherlands, 1988.
*11. Oberley TD and Murphy-Ullrich JE: Fibronectin and the kidney. In: Fibronectin. DF Mosher, Ed, Academic Press, pp. 309-326, 1989.
*12. Oberley TD, Oberley LW: Oxygen radicals and cancer. In: Free Radicals and Aging, Yu B (ed.), CRC Press, Boca Raton, FL, pp. 247-267, 1993.
13. Oberley LW, Oberley TD: Reactive oxygen species in the etiology of cancer. In: Drugs, Diet, and Disease, Ioannides C (eds.), Prentice-Hall, Herts, England, pp. 49-63, 1994.
*14. Oberley TD, Oberley LW: Localization of antioxidant enzymes during development. In: The Oxygen Paradox (ed by KJA Davies and F Ursini), CLEUP University Press, Padova, Italy, 1995, pp 337-348.
15. Oberley LW, Oberley TD: Oxyradicals and malignant transformation. In: Oxy-radicals in Medical Biology, McCord JM (ed.), Jai Press, Greenwich, CT, 1995.
16. Oberley LW, Oberley TD: Role of antioxidant enzymes in the cancer phenotype. In: Oxygen, Gene Expression and Cellular Function, Clerch L, Massaro D (eds), Marcel Dekker, Intl., New York, 1997.
*17. Oberley, T.D. Ultrastructural localization and relative quantification of 4-hydroxynonenal-modified proteins in tissues and cell compartments. In: Methods in Enzymology, Academic Press, vol. 352, chapter 32, pp. 373-377, 2002.
18. Cole, M.P.; Chaiswing, L.; Oberley, T.D.; Kiningham, K.K.; St. Clair, D. Superoxide, Superoxide Dismutases, and Cardiovascular Dysfunction, In: Mechanisms of Cardiovascular Aging, Elsevier Science, ed. by T. Hagen, vol. 11, 233-280, 2002.
Abstracts (selected abstracts only):
1. Oberley TD, Burkholder PM, and Barber TA: Complement receptor on glomerular capillary epithelial cells. Amer Soc Nephrol, 1976.
2. Oberley TD, and Burkholder PM: Morphologic and biochemical characteristics of cultured adult renal glomerular cells. Int Congress Nephrol,1978.
3. Steinert BW, and Oberley TD: Growth of primary glomerular and tubular cells in vitro in a chemically defined serum-free medium. Fed Proc, Chicago, April, 1983.
4. Murphy-Ullrich JE and Oberley TD: Tissue injury in mice immunized with laminin. Fed Proc, Chicago, April, 1983.
5. Oberley TD: The role of fibronectin in the growth of primary glomerular explants in serum-free media. UCLA Symposium. Extracellular Matrix: Structure and Function, April, 1984.
6. Steinert BW, Anderson PJ, and Oberley TD: Analysis of glomerular cell outgrowth in serum-free media: Correlation with reactive oxygen metabolism. Fed Proc, Anaheim, CA, April, 1985.
7. Willson JKV, Bittner GN, Oberley TD, and Weese JL: Primary and continuous culture of human colonic adenomas, carcinomas, and metastases. AACR, Houston, TX, May, 1985.
8. Hopkins WJ, Reznikoff CA, Oberley TD, Berens LJ, and Uehling DT: Adherence of uropathogenic Eschericia coli to differentiated human uroepithelial cell in vitro. American Society of Microbiology, 1986.
9. Christian BJ, Loretz LJ, Oberley TD, and Reznikoff CA: Chemical transformation of human uroepithelial cells immortalized by SV40 virus. Proc Am Assoc Cancer Res, 1986.
10. Oberley TD, Li JJ, Li SA, and Goldfarb S: Growth of Syrian hamster proximal tubular cells in chemically defined media: Stimulation by estrogens. Seventy-eighth annual meeting of the American Association for Cancer Research, May 20-23, 1987.
11. Bittner GN, Oberley TD, Meisner LF, Willson JKV: Characterization of cell lines derived from human adenomatous polyps. Proc Am Assoc Cancer Res, 1987.
12. Pugh TD, Goldfarb S, Oberley TD, Li SA: Hyperplasia of kidney tubular cells during estrogen-induced renal carcinogenesis in the Syrian hamster. Proc Am Assoc Cancer Res, 1987.
13. Gonzalez A, Oberley TD, Li JJ: Morphologic and immunohistochemical analysis of the estrogen induced Syrian hamster tumor. Proc Am Assoc Cancer Res, 1988.
14. McCormick M, Elwell J, Oberley LW, Sun Y, Oberley TD, and Li JJ: Superoxide dismutase and catalase levels in fetal and mature kidneys and estrogen-induced Syrian hamster renal cancer. Proc Am Assoc Canc Res, 1989.
15. Schiller JH, Bittner G, Meisner LF, Oberley TD, Norback D, and Carr R: Characterization of an EBV-transformed lymphoblastoid cell line derived from a hairy cell leukemia patient. Proc Am Assoc Canc Res, 1989.
16. Gonzalez A, Oberley TD, and Li JJ: Ultrastructural and immunohistochemical studies of early lesions in estrogen-induced Syrian hamster renal neoplasms. Proc Am Assoc Canc Res, 1989.
17. Oberley TD, Lauchner LJ, Li SA, and Li JJ: Estrogen-induced proliferation of hamster proximal tubular epithelium in culture: Relation to estrogen carcinogenicity. Proc Am Assoc Canc Res, 1989.
18. Gonzalez A, Oberley TD, and Li JJ: Long-term cultures of DES-induced Syrian hamster tumor cells retain their malignant potential in vivo and in vitro. Proc Am Assoc Canc Res, abstract #644, 1990.
19. Rago R, Mitchen J, Cheng A, Oberley TD, and Wilding G: Metabolic effects of suramin on human prostate cancer cells. Proc Am Assoc Canc Res, abstract #1288, 1990.
20. Cihla HP, Coursin DB, Bindley CD, Oberley TD, and Oberley LW: Immunohistochemical localization of pulmonary antioxidant enzymes. Histochemistry Society, 1990.
21. Coursin DB, Cihla HP, Bindley CD, Wallow IH, Oberley TD, and Oberley LW: Electron microscopic localization of antioxidant enzymes in rat lung. Am Soc Anesth, 1990.
22. Safford SE, Oberley TD, Urano M, St. Clair DK: Overexpression of manganese superoxide dismutase suppresses the metastasis of transplanted fibrosarcoma, First Annual Meeting of the Oxygen Society. Free Radic Biol Med 15; 3:4, 1993.
23. Oberley TD: Cell type specific modulation of antioxidant enzymes during hamster kidney development. First Annual Meeting of the Oxygen Society. Free Radic Biol Med 15; 10:4, 1993.
24. Mitchen J, Oberley T, Wilding G: Extended culturing of primary human epithelial prostate cells by continuous treatment with collagenase (CLS III). Proc Amer Assoc Cancer Res, 34:247, 1993.
25. Ripple M, Sempf J, Oberley T, Wilding G: Changes in GSH- and antioxidant-related enzymes in mephalan resistant prostate carcinoma cells. Proc Amer Assoc Cancer Res 35:378, 1994.
26. Oberley TD, Li N: Transfection of cDNA for manganese superoxide dismutase (MnSOD) into prostate carcinoma cells results in increased sensitivity to oxidative stress and redox cycling drugs. Annual Meeting Oxygen Society, Pasadena, CA, 1995.
27. Suzuki K, Oberley T, Pugh T, Weindruch R: Influence of caloric restriction and age on antioxidant enzymes in the prostates of rats. American Aging Association, San Antonio, TX, 1995.
28. St. Clair DK, Oberley TD, Yen CH, Chow CK: Expression of manganese superoxide dismutase systemically suppressed adriamycin-induced tissue injury in transgenic mice. Oxidant Stress and Liver Disease, FASEB Conf., 1995.
29. Ho YS, Oberley TD, Gargano M: Increased pulmonary glutathione peroxidase activity provides no protection to mice exposed to hyperoxia. American Thoracic Society, Seattle, WA, 1995.
30. Yen HC, Oberley TD, Vichitbandha S, St. Clair DK: Human manganese superoxide dismutase transgenic mice are protected against adriamycin-induced cardiac toxicity. Society Toxicology, 1995.
31. Reddig PJ, Dreckschmidt NE, Oberley TD, Verma AK. Transgenic mice overexpressing protein kinase C d in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). American Assn. For Cancer Res.; vol. 40, abstract #645, p. 97, March, 1999 (Philadelphia, PA).
32. Elegbede JA, Pompilius M, Oberley TD, Verma AK. Okadaic acid-induced apoptosis is accompanied by the production of reactive oxygen species and release of tumor necrosis factor alpha. American Assn for Cancer Res.; vol. 40, abstract #1477, p. 223, March, 1999 (Philadelphia, PA).
33. Reddig PJ, Dreckschmidt NE, Oberley TD, Verma AK. Transgenic mice overexpressing protein kinase C e in the epidermis exhibit hyperproliferation and ulceration of the skin. American Assn. for Canc. Res.; vol. 40, abstract # 3325, p. 504, March, 1999 (Philadelphia, PA).
34. Reddig PJ, Dreckschmidt NE, OberleyTD, Verma AK. Transgenic mice overexpressing protein kinase Cd in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). ASBMB Symposium on Protein Kinase C and Cellular Function, Oct. 9-12, 1998, Abstract 78.
35. Zainal TA, Pugh TD, Oberley TD, Weindruch R. Histological assessment of oxidative damage in aging skeletal muscle. American Aging Assn, Seattle, WA, 1999.
36. Zainal T.A, Oberley TD, Weindruch R. Histological study of age-associated oxidative damage in skeletal muscle from rhesus monkeys. Plant and Wine Polyphenol Antioxidants in the Biology and Pathology of Free Radicals, Santiago, Chile, July 29-30, 1999.
37. Oberley TD. Antioxidant enzymes and oxidative damage products in human prostate cancer, Oxygen Society, New Orleans, LA, Nov. 1999.
38. Hall DM, Oberley TD, Buettner GR, Xu L, Drake VJ, Swartz S, Oberley LW, Kregel KC. Aging Increases the systemic levels of redox active transition metals and blunts liver antioxidant enzyme expression in response to heat stress, Oxygen Society, New Orleans, LA, Nov, 1999.
39. Kay HH, Grindle KM, Oberley TD, Magness RR. Ethanol exposure in human placental villi induces oxidative damage. Society Gynecology Investigation, 2000.
40. Nessel R, Ching T, Oberley T, Hullett D, Sollinger HW. Prolongation of canine allograft survival with VX-497. Transplant 2000, May 2000, Chicago, IL.
41. Nessel R, Hullett D, Oberley T, DeLuca H, Sollinger H. Prolongation of rat kidney allografts using 1,25(OH)2D3 as the sole immunosuppressive agent. Transplant 2000, May 2000, Chicago, IL.
42. Zou J, Jansen AP, Dreckschmidt NE, Reddig PJ, Oberley TD, Verma AK. PKC isoforms cross-talk in mouse skin papillomas from transgenic mice overexpressing PKCδ and wild type FVB/N mice. Amer. Assoc. Canc. Res., April 2000, San Francisco, CA.
43. De Las Casas L, Oberley TD, Pirsch JD, Wetzel DJ, Kurtycz DFI, Hoerl HD. Utility of urinary cytology for diagnosing polyoma (BK) virus infection in renal transplant recipients; a study of 32 cases with electron microscopic analysis. American Society of Cytopathology, 2000.
44. Ball MC, Oberley TD, Lin S-M, Hines JN, St. Clair DK. Generation and characterization of inducible nitric oxide synthase (iNOS) knock-out and over-expressing manganese superoxide dismutase (MnSOD) cross-breed model for investigation of the role of nitric oxide (NO) in adriamycin (ADR)-induced cardiac toxicity. Oxygen Society, San Diego, CA, November, 2000.
45. Wang L, Oberley T, St. Clair DK. Tamoxifen (TAM) protects cardiac cells from injury induced by TNF-a. Oxygen Society, San Diego, CA, November, 2000.
46. Zhao Y, Oberley TD, Kiningham KK, Hines J, Lin S-M, St. Clair DK. Overexpression of MnSOD suppresses tumor promotion by modulating AP-1 signaling in a multistage skin carcinogenesis model. Oxygen Society, San Diego, CA, November, 2000.
47. Lin S-M, Oberley TD, Kiningham KK, St. Clair DK. Exacerbation of cardiotoxicity induced by adriamycin in tumor necrosis factors knockout mice. Oxygen Society, San Diego, CA, November, 2000.
48. Torrealba JR, Oberley T, Schultz JM, Brunner K, Peters D, Fechner JH, Dong Y, Cho CS, Fernandez L, Knechtle SJ. Immunotoxin-treated rhesus monkeys: a model for renal allograft chronic rejection. Transplantation, May 2001.
49. Swaminathan S, Burger MS, Torino JL, Oberley TD. DNA damage in human transitional cell carcinoma (TCC) cells following exposure to N-hydroxy-aminoacetylaminobiphenyl, the proximate carcinogenic metabolite of the human bladder carcinogen 4-aminobiphenyl. Abstract published in Environmental and Molecular Mutagenesis, vol. 37, supplement 32, 73, 2001.
50. Huang T-T, Oberley T, Srinivasan C, Mantha S, Epstein C, Valentine J, Gralla E. CuZn superoxide dismutase deficiency leads to unbalanced iron metabolism and the development of hepatocellular carcinoma. Int. Meeting on Copper Homeostasis and Its Disorders, 2001.
51. Zhao Y, Oberley TD, Chaiswing L, Lin S, Epstein CJ, Huang TT, St. Clair D. Tumorigenesis is regulated by modulation of AP-1 and p53-mediated pathways in manganese superoxide dismutase heterozygous knockout mice. Oxygen Society, North Carolina, November 2001.
52. Kim A, Zhong W, Oberley TD. Inducible overexpression of manganese superoxide dismutase inhibits cell cycle progression in NIH/3T3 fibroblast cells. Oxygen Society, North Carolina, November 2001.
53. Mantha S, Oberley TD, Epstein CJ, Huang TT. Hepatocellular carcinoma and altered aconitase activities in CuZn superoxide dismutase deficient mice. Oxygen Society, North Carolina, November 2001.
54. Torrealba J, Schultz J, Kusaka S, Fechner J, Oberley T, Knechtle S, Burlingham W. TGFb staining of human and rhesus monkey kidney transplant biopsies correlates with immune regulation of rejection status. Immunology Conference, Chicago, November 2001.
55. Torrealba J, Fernandez L, Schultz J, Yaggi Y, Oberley T, Knechtle S, Hamawy M. Decrease of macrophages and cytotoxic T cells is implicated in renal allograft acceptance in rats treated with Piceatannol in combination with subtherapeutic doses of cyclosporine A. Immunology Conference, Chicago, November 2001.
56. Torrealba J, Schultz J, Fernandez L, Oberley T, Knechtle S, Hamawy M. Linker for activation of T cells(LAT) is increased in renal allograft rejection in rhesus monkeys. Immunology Conference, Chicago, November 2001.
57. Wheeler DL, Dreckschmidt NE, Hayes KL, Oberley TD, Ananthaswamy HN, Verma AK. Alpha-difluoromethylornithine-induced inhibition of the development of metastatic squamous cell carcinomas accompanied by a marked regression of hair follicle growth and alopecia in protein kinase C epsilon transgenic mice. AACR, San Francisco, April, 2002.
58. Cole MP, Oberley TD, Lin SM, Kiningham KK, St. Clair DK. Loss of adaptive response to oxidative stress and exacerbation of adriamycin (ADR)-induced cardiac injury in inducible nitric oxide synthase homozygous knock-out mice (iNOS(-/-)). Oxygen Society, North Carolina, November, 2001.
59. Torrealba J, Oberley T, Schultz J, Fechner JH, Dong Y, Hamawy MH, Knechtle SJ. CD68+ macrophage infiltrates are correlated with the severity of chronic rejection in an immunotoxin-treated rhesus monkey model of chronic renal allograft rejection. American Transplant Congress, 2002.
60. Torrealba J, Schultz J, Oberley T, Manthei E, Scheunemann TL, Chang Z, Knechtle SJ, Hamawy MM. The signaling molecule linker for activation of T cells (LAT) as a marker for renal allograft rejection in monkeys. American Transplant Congress, 2002.
61. Hamawy MM, Torrealba J, Fernandez L, Schultz J, Yagei G, Oberley T, Manthei E, Fechner JH, Knechtle SJ. Piceatonnol in combination with cyclosporin A attenuates macrophage and cytotoxic T cell infiltration into transplanted rat kidneys. American Transplant Congress, 2002.
62. Burlingham WJ, Torrealba J, Schultz J, Katayama M, Kusaka S, Jankowska-Gan E, Fechner JH, Oberley T, Hamawy MM, Knechtle SJ. Distinct transforming growth factor beta (TGFb) staining patterns of transplant acceptance vs. rejection in rhesus monkey renal allografts: correlation with DTH regulation status. American Transplant Congress, 2002.
63. Torrealba J, Oberley TD, Knechtle SJ.. CD68+ macrophage infiltrates are correlated with the severity of chronic rejection in an immunotoxin-treated rhesus monkey model of chronic allograft rejection, XIX International Congress of the Transplantation Society, Miami, FL, August 25-30, 2002.
64. Torrealba J, Oberley TD, Knechtle SJ. Prolongation of kidney allograft survival by piceatannol in combination with sub-therapeutic doses of cyclosporin A is associated with reduced mononuclear infiltrates into the transplanted kidney, XIX International Congress of the Transplantation Society, Miami, FL, August 25-30, 2002.
65. Hamawy MM, Torrealba J, Schultz J, Oberley T, Cho C, Manthei E, Scheunemann TL, Chang Z, Fechner J, Knechtle SJ. The signaling molecule linker for activation of T cells (LAT) as a maker for renal allograft rejection in rhesus monkeys, XIX International Congress of the Transplantation Society, Miami, FL, August 25-30, 2002.
66. Wheeler DL, Dreckschmidt
N, Hayes KL, Oberley TD, Ananthaswamy HN, Verma AK. Inhibition of metastatic
squamous cell carcinoma by a-difluoromethylornithine accompanied by a marked
regression of hair follicle growth and alopecia in protein kinase C e transgenic
mice. Abstract #5013, page 1011, Proceedings of the American Association for
Cancer Research, San Francisco, CA, April 6-10, 2002.
67. Chaiswing L, Oberley TD, Cole MP, Szweda LI, Itarat W, St. Clair D. In vivo analysis of ROS/RNS in adriamycin-induced cardiotoxicity. Oxygen Society, San Antonio, TX, November, 2002. Luksana Chaiswing was an international graduate student in Dr. Oberley’s laboratory. She was one of five students selected to receive a travel award to present this work at the Oxygen Society.
68. Mantha SV, Oberley TD, Van Remmen H, Epstein CJ, Huang T-T. Increased oxidative stress and dysregulation of cell cycle proteins in CuZnSOD deficient mice. Oxygen Society, San Antonio, TX, November, 2002.
69. Zhang HJ, Doctrow SR, Xu L, Oberley TD, Kregel KC. A synthetic superoxide dismutase (SOD)/catalase mimetic protects heat stress-induced liver injury in aged rats. Oxygen Society, San Antonio, TX, November, 2002.
70. Zhao Y, Wang L, Chaiswing L, Oberley T, Yen H, Lin S, St. Clair D. Tamoxifen protects against TNF alpha-induced mitochondrial dysfunction in cardiac tissues. Oxygen Society, San Antonio, TX, November 2002.
71. Kim A, Oberley LW, Oberley TD. Inhibition of cell growth by MnSOD overexpression in human fibroblasts. Oxygen Society, San Antonio, TX, November, 2002. Ms. Kim received a Vilas travel award to present this poster.
72. Li N, Wang M, Oberley T, Sempf J, Nel A. Comparison of the pro-oxidative and pro-inflammatory effects of organic DEP chemicals in bronchial epithelial cells and macrophages. Oxygen Society, San Antonio, TX, November, 2002.
73. Cole MP, Lin SM, Chaiswing L, Kiningham KK, Oberley TD, St. Clair DK. Intricate relationship between nitric oxide (NO) and superoxide dismutase (SOD) in the protection against adriamycin (ADR)-induced cardiotoxicity. Oxygen Society, San Antonio, TX, November 2002.
74. Torrealba J, Fernandez LA, Yagci G, Schultz J, Oberley TD, Manthei ER, Fechner J, Knechtle S, Hamawy MM: Piceatannol is associated with increased survival and reduced mononuclear cells in renal allografts, ASCP/CAP Annual Meeting, Washington DC, October 2002. Dr. Torrealba received an award as the best abstract by a resident at the meeting.
75. Wheeler DL, Ness KJ, Dreckschmidt NE, Oberley TD, Verma AK. The role of proinflammatory cytokine TNFa in PKCe signaling network in the development of metastatic squamous cell carcinomas. Fifth International Skin Carcinogenesis Meeting, Gifu, Japan, October, 2002.
76. Lin T-M, Fritz WA, Oberley TD, Moore RW, Peterson RE. Prostate tumor progression in the TRAMP mouse: regulation by the aryl hydrocarbon receptor (AhR). AACR, 2003. This abstract was selected for a minisymposium presentation at the meeting.
77. Zhao Y, Chaiswing L, Oberley TD, St. Clair D. Tamoxifen protects against TNFa-induced cardiac injury via a novel p75 receptor-mediated pathway. AACR, 2003.
78. Torrealba J, Rao V, Foley DP, Luis F, Zhong W, Friedl A, Pirsch JD, Oberley TD: Peritubular C4d depostion in renal allografts is associated with early transplant glomerulopathy. American Transplant Congress, 2003.
79. Torrealba, J, Oberley, TD, Knechtle SJ: TGFB-dependent immunoe regulation during renal allograft acceptance. Association of latent TGFB+, CD4+ lymphocytic graft infiltrates with a regulated DTH response of rhesus monkey PBMC to donor antigen. American Transplant Congress, 2003. Dr. Torrealba received a Young Investigator Award for this abstract.
80. Wheeler DL, Ness KJ, Dreckschmidt NE, Oberley TD, Verma AK. Protein kinase C epsilon transgenic mice: A unique model to investigate myeloproliferative diseases. Proc AACR, Toronto 2003.
81. Wheeler DL, Ness KJ, Dreckschmidt NE, Oberley TD, Verma AK. TPA-stimulated serum tumor necrosis factor a (TNF a) levels in PKC e transgenic mice: possible link with PKC e-mediated increased tumor necrosis factor converting enzyme (TACE) and development of metastatic squamous cell carcinoma. Proc AACR, Toronto, 2003.
82. Li Y, Wheeler DL, Verma AK, Oberley TD. Inflammation plays an important role in the protein kinase C e-mediated response to 12-O-tetradecanoylphorbol-13-acetate. Soc. for Invest. Derm., 65th Annual Meeting, Miami Beach, FL, 2003.
83. Wheeler DL, Ness KJ, Dreckschmidt NE, Oberley TD, Verma AK. Protein kinase C e (PKC e) transgenic mice: A unique model to investigate myeloproliferative-like syndromes, a group of pre-hematopoetic neoplasms. AACR Mouse Models of Cancer. Orlando, 2003.
84. St. Clair DK, Zhao Y, Oberley T. Redox-mediated skin tumor formation: The role of manganese superoxide dismutase. Association of Photobiology, 2003.
85. Zhao Y, Chaiswing L, Oberley TD, Batinic-Haberle I, Fridovich I, Epstein CJ, Huang T-T, St. Clair D. Mechanisms based modulation of skin carcinogenesis by SOD mimetic in manganese superoxide dismutase deficiency mice. Oxygen Society, Seattle, WA, 2003.
86. Djamali A, Sprague J, Jacobsen L, Yracheta J, Oberley T, Hulett D, Becker B. Intragraft expression of HSP 27 in a murine model of chronic allograft nephropathy. American Society of Nephrology Annual Meeting, San Diego, CA, 2003.
87. Chaiswing L, Oberley TD, Cole MP, Ittarat W, St. Clair. Changes in ROS/RNS levels in mitochondria precede adriamycin-induced cardiac mitochondrial ultrastructural changes. Oxygen Society, Seattle, WA, 2003. Ms. Chaiswing received a travel award to present this poster.
88. Zhang Y, Church D, Thompson TA, Zhong W, Wilding G, Oberley TD. Vitamin E modulates androgen induced oxidative stress and enhances cell death in LNCaP human prostate carcinoma cells. Oxygen Society, Seattle, WA, 2003.
89. Deery SE, Noel T, Chaiswing L, Lin S-M, Oberley TD, St. Clair DK. MnSOD and TNF-alpha mediated cardioprotection during adriamycin treatment. Oxygen Society, Seattle, WA, 2003.
90. Kim A, Oberley TD. Modulation of endogenous MnSOD expression by inducible overexpression of exogenous MnSOD. Oxygen Society, Seattle, WA, 2003.
91. Zhang HJ, Xu L, Kregel KC, Oberley TD. Aging produces differential hepatic injury in response to hyperthermic challenge. Oxygen Society, Seattle, WA, 2003.
92. Bourdeau-Heller JM, Oberley TD. The effect of oxygen adaptation on the redox environment of a prostate cancer cell line. Oxygen Society, eattle, WA, 2003.
93. Cole M, Chaiswing L, Oberley T, Kiningham K, St. Clair D. Reactive oxygen species generated by adriamycin (ADR) play a central role in the distribution of transcription factors between nuclear and mitochondrial compartments. Oxygen Society, Seattle, WA 2003.
94. Torrealba J, Katayama M, Fechner Jr JH, Jankowska-Gan E, Kusaka S, Xu Q, Schultz JM, Oberley TD, Hu H, Hamawy MM, Knechtle SJ, Burlingham WJ. Transforming growth factor b-mediated immune regulation of accepted renal transplants correlates with infiltrating TGFb+ T-regulatory cells in the allograft. Pathology Society, 2003. Dr. Torrealba received an award for the best poster at this meeting.
95. Thompson TA, Church DR, Zhong W, Oberley TD, Wilding G. Terminal differentiation induction in LNCaP human prostate cancer cells. Proc Am Assoc Cancer Res 45:889 (A3852), 2004.
96. Bourdeau-Heller J, Oberley TD. Changes in superoxide levels during growth in non-synchronized prostate cancer cell lines adapted to growth in different oxygen levels. Society for Free Radical Biology and Medicine, Virgin Islands, November, 2004.
97. Bourdeau-Heller J, Oberley TD. Unique effects of oxygen adaptation on redox microenvironments in a prostate cancer cell line. Society for Free Radical Biology and Medicine, Virgin Islands, November, 2004.
98. Zhang HJ, Oberley LW, Oberley TD, Kregel KC. Heat stress produces differential ultrastructural damage in young and old rats. Society for Free Radical Biology and medicine, Virgin Islands, November 2004.
99. Zhao Y, Chaiswing L, Velez JM, Batinic-Habele I, Colburn NH, Oberley TD, St. Clair DK. P53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Society for Free Radical Biology and Medicine, Virgin Islands, November 2004.
100. Bourdeau-Heller J, Schell K, Oberley TD. Quantification of ROS in phases of the cell cycle in a prostate cancer cell line by flow cytometry. Great Lakes International Imaging and Flow Cytometry Association, Windsor, Ontario, Canada, October 2004.
101. Li Y, Wheeler DL, Ananthaswamy H, Chaiswing L, Verma AK, Oberley TD. Analysis of early morphologic changes and cytokine levels in mouse skin following a single 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate treatment: the effect of constitutive expression of PKCe. AACR, 2004.
102. Li Y, Wartman M, Wheeler DL, Dreckshmidt N, Verma AK, Oberley TD. Rapid induction of metastatic squamous cell carcinoma in skin from PKCe overexpression transgenic mice but resistance to papilloma formation in wild type mice following two doses of 7,12-dimethylbenz[a]anthracene. AACR, 2004.
103. Lien Y-C, Noel T, Nithopongvanitch R, Oberley T, St. Clair D. TNF receptors suppress the Fas-mediated pathway and protect against Adriamycin-induced intrinsic cell death pathway in cardiomyocytes. Society for Free Radical Biology and Medicine, Virgin Islands, November 2004.
104. Cole M, Chaiswing L, Oberley T, Kiningham K, St. Clair D. Overexpression of MnSOD suppresses P53-mediated ADR-induced cardiac injury in mice lacking iNOS. Society for free Radical Biology and Medicine, Virgin Islands, November 2004.
105. Velez J, Kiningham K, Zhao Y, Oberley T, St. Clair D. Interaction between MnSOD and P53 reveals a mitochondrial-mediated mechanism of taxol-induced peripheral neuropathy. Society for Free Radical Biology and Medicine, Virgin Islands, November 2004.
106. Smavatkul C, Baba F, Oberley T, Chin T, Becker Y, Becker B, Samaniego M. C4D+ chronic allograft nephropathy (CAN): Clinicopathologic characteristics and transplant outcomes. American Transplant Congress, 2004.
107. Li Y, Wartman M, Wheeler DL, Dreckschmidt N, Verma AK, Oberley TD. Increased skin tumor initiating dose enhances epidermal cell apoptosis, mast cell infiltration and oxidative stress in PKC epsilon overexpressing transgenic mice, which develop metastatic squamous cell carcinomas. Abstract # 3925, p. 924. AACR, Anaheim CA, 2005.
108. Li Y, Wheeler DL, Alters W, Chaiswing L, Verma AK, Oberley TD. Protein kinase C epsilon overexpressing transgenic mice and development of papilloma-independent squamous cell carcinoma: Role of altered cell kinetics and inflammatory cytokines. Abstract # 1186, p. 276. AACR, Anaheim CA, 2005.
109. Zhao Y, Chaiswing L, Velez, J, Batinic-Haberle I, Colburn N, Oberley T, St. Clair D. p53 translocation to mitochondria precedes it nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Abstract #5280, p. 1248. AACR, Anaheim, CA, 2005.
110. Zhao Y, Chaiswing L, Oberley TD, St. Clair DK: Ras mutations promote p53 activation and apoptosis of skin keratinocytes. FRBM, Austin, TX, 2005.
REVIEW ACTIVITIES:
Guest Editor, Antioxidants and Redox Signaling, Forum on “Redox State and Carcinogenesis”
Free Radical Biology and Medicine(x17 manuscripts reviewed in 2005)
Biochemical Journal (started October 2005)
Manuscript Review:
Dr. Oberley has served as an hoc reviewer for the following journals:
a. J. Histochemistry and Cytochemistry
b. Laboratory Investigation
c. Journal of Theoretical Biology
d. Dialysis and Transplantation
e. Archives Biochemistry and Biophysics
f. Cell Differentiation
g. J. Cell Biology
h. Cancer Research
i. Toxicology In Vitro
j. In Vitro Cellular and Developmental Biology
k. J. Lipid Research
l. Free Radical Biology and Medicine
m. J. Toxicology and Environmental Health
n. American Journal of Pathology
o. British Journal of Cancer
p. Journal of Biological Chemistry
q. Enviromental Health Perspectives
r. Histochemical Journal
s. Proceeding of the National Academy of Sciences USA
t. Proceedings of the Society for Experimental Biology and Medicine
u. Life Sciences
v. Carcinogenesis
w. Diabetes
x. J. Applied Physiology
y. Brit. J. Cancer
z. The Prostate
aa. J. Neuropathology and Experimental Neurology
bb. Archives of Pathology and Laboratory Medicine
cc. Nutrition and Cancer
dd. J. Experimental Biology
ee. Chemical Research in Toxicology
ff. Cancer Detection and Prevention
hh. International Journal of Cancer
ii. Tissue and Cell
jj. Clinical Cancer Research
kk. Microscopy and Microanalysis
ll. Pediatric Nephrology
mm Kidney International
nn. Biochemical Journal
Journal Review in 2004-2005
Biochemical Journal
Nutrition and Cancer
FEBS Letters
Biochemical Journal
J. Endocrinology
American J of Pathology(x3)
Oncogene
Archives of Pathology and Laboratory Medicine
Molecular Carcinogenesis
International Journal of Cancer
J Neuropathology and Experimental Neurology
Asian Journal of Andrology
Grant Review:
Ad hoc reviewer for NIH
Ad hoc reviewer for March of Dimes
Ad hoc reviewer for National Science Foundation
Ad hoc reviewer for the Veterans Administration Research Service
Department of Energy Study Section, 1999.
University of Iowa Diabetes and Endocrinology Research Center, 2001
U.S. Civilian Research and Development Foundation for joint Russian-U.S. research, 2001
Association for International Cancer Research, December, 2002
Review in 2004-2005:
NIH Program Project Review, University of Iowa, “Oxidative Events in Cancer Therapy”, March 16, 2005.
National Research Council of Singapore, reviewed two grant applications in the area of oxidative stress to date.
National Medical Research Council, Singapore (x 2)
2004 Pilot Grant Program of the Barshop Center for Longevity and Aging Studies, Univ. Texas Health Sciences Center-San Antonio
NIH Study Section on “Mitochondrial Oxidative Stress in Diabetes and Obesity,” 2005. I declined this invitation because of a previous commitment to consult at the University of Kentucky at the same time.
MEETINGS AND PRESENTATIONS:
Invited Participation in National Meetings:
Invited discussant, Gordon Research Conference on Hormonal Carcinogenesis, Aug, 1987.
Chairperson, American Association for Cancer Research Slide Session, "Cell Biology in Vitro: Oxygen Radicals", May, 1987.
Invited discussant, NIH Conference on Hormonal Carcinogenesis, May, 1987.
Invited discussant, NIH Conference on Hormonal Carcinogenesis, Sept., 1989.
List of Invited Research Presentations:
University, National, and International:
1. Immune Mechanisms in Renal Disease, N.I.H., "Culture of Kidney Glomeruli", November, 1979.
2. International Congress of Nephrology, Montreal, "Culture of Kidney Glomeruli", June, 1979.
3. Basic Science Lecture Series, St. Clare Hospital, Monroe, Wisconsin, "Renal Pathology", November, 1981.
4. UCLA Symposium on Extracellular Matrix, Keystone, Colorado: "Role of Fibronectin in Glomerular Cell Outgrowth in Serum-free Media", April, 1984.
5. International Congress of Nephrology Satellite Symposia on Glomerular Function, San Diego, California: "Role of Fibronectin in Glomerular Cell Outgrowth in Serum-free Media", June, 1984.
6. Dept. of Nephrology, Medical College of Wisconsin: "Growth of Kidney Cells in Serum-Free Media," May 1984.
7. Dept. of Oral Biology and Molecular Biology, Northwestern University Dental School, April, 1985, "Role of active oxygen metabolites and fibronectin in glomerular cell outgrowth”
8. International Congress of Nephrology, invited lecturer, "Identification of Glomerular Cells in Culture", London, England, 1987.
9. National Kidney Foundation, Madison, Wisconsin: "The role of the extracellular matrix in kidney tubular cell differentiation in culture", 1988.
10. Midwest Toxicology Symposium, Madison, Wisconsin: "The role of estrogens in development of kidney cancer in the Syrian hamster", 1989.
11. First Annual Meeting of the Oxygen Society, Charleston, SC: "Cell-type specific modulation of antioxidant enzymes during hamster kidney development", 1993.
12. NIH Workshop on Occupational Exposures, Bethesda, MD: "Human kidney tumor pathology", 1994.
13. International Amyotrophic Lateral Sclerosis Symposium, Chicago, IL: “Localization of antioxidant enzymes,” Sept., 1995
14. The 50th Annual Scientific Meeting of the Gerontological Society of America, Cincinnati, OH, Nov., 1997, “Morphologic assessment of oxidative stress in vivo using oxidative damage-specific antibodies.”
15. UW Toxicology program: “Methods for measuring oxidative damage.”
16. UW Comprehensive Cancer Center:”Effects of MnSOD overexpression on cell cycle.”
17. NCI Symposium of MnSOD and Cancer (August 1999, Lexington, KY): “Antioxidant enzymes and oxidative damage products in human prostate cancer.”
18. University of Iowa, Radiation Biology Program: “Morphologic assessment of oxidative damage,” Oct 14, 1999
19. “The effect of prooxidant/antioxidant balance on the cell cycle”, Dept. of Pathobiological Science, University of Wisconsin School of Veterinary Medicine, April 28, 2000, audience approximately 50.
20. “Morphologic assessment of oxidative damage,” American Aging Association, Boston, MA, June 3, 2000, audience approximately 100.
21. “Morphologic assessment of oxidative damage,” Toxicology Program, University of Kentucky, October 22, 2000.
22. “Morphologic assessment of oxidative damage,” UW Department of Pathology, October 25, 2000.
23. “Morphologic Assessment of Oxidative Damage” and “Redox Regulation of the Cell Cycle, “ combined meeting of the Radiation Research Society and the Hyperthermia Society, San Juan, Puerto Rico, April 23, 2001, each lecture audience approximately 100.
24. “Oxidative stress signaling pathway in mouse skin tumor promotion, “ Developmental Toxicology meeting, Madison, WI, audience approximately 50, June 7-8, 2001.
25. “Oxidative damage in rhesus monkey skeletal muscle and retardation by caloric restriction,” American Aging Assn, June 1, 2001, audience approximately 50.
26. “Antioxidant compounds: benefits and risks,” Developmental Toxicology meeting, Madison, WI, Dr. Oberley Symposium leader with introductory lecture, audience approximately 100, Madison, WI, June 7, 2001.
27. I have presented numerous Departmental seminars.
28. The 2nd Internaltional Conference on Prostate Cancer Research, October 12-15, 2002, Iowa City, Iowa, audience approximately 100.
29. “Cell Redox State and Prostate Cancer,” Prostate Working Group-UW-Madison, Oct. 31, 2002, audience approximately 25.
30. Nephrology Grand Rounds, February 24, 2004, “Oxidative Stress, “ audience 15.
31. “Is oxidative stress involved in aging and cancer?” ,University of Wisconsin Aging Training Grant Program, October 20, 2005.
32. “Redox regulation of human prostate cancer cell growth, “ O’Brien Center and Aging and Cancer Center Symposium, January 6, 2006, audience 75.
RESEARCH SUPPORT:
1. "In Vitro Culture Studies of Renal Glomerular Diseases.” N.I.H., $75,000, 9-15-75 to 8-30-78, P.M. Burkholder, Principal Investigator, Terry D. Oberley, Co-Principal Investigator.
2. "Ultrastructural immunohistochemical localization of antigens and enzymes within the renal glomerulus in vivo and in cultured glomerular cells in vitro.” University of Wisconsin Medical and Graduate Schools, $12,000, 11-1-77 to 1-30-78.
3. “Immunohistochemical and Biochemical Studies of Hereditary Nephritis.” March of Dimes, $42,220, 9/78-6/81.
4. "Does fibronectin interact with cell membrane ligatin?" ACS Institutional Grant, $5,000, 9-1-79 to 8-31-80.
5. "Antigenic and Biochemical Analysis of Glomerular Basement Membrane.” University of Wisconsin Medical and Graduate Schools, $12,000, 7-1-79 to 6-30-80.
6. Immunobiology Training Grant (support of Ms. Joanne Murphy-Ulrich), $1,000, 1979-80.
7. Environmental Toxicology Training Grant (support for Mr. Bruce Steinert), $400, 7/80-6/81.
8. "Immunologic and biochemical studies of hereditary nephritis.” National Kidney Foundation of Wisconsin, $1000, 7-1-80 to 6-30-81.
9. "Development of Tissue Culture Techniques for the Study of Hereditary Renal Disease.” Hereditary Nephritis Foundation, $2000, 10-10-80 to 10-9-81.
10. "Studies of Experimental Autoimmune Disease.” Dane County Medical Society, $4000, 9-1-80 to 8-31-81.
11. "Morphologic and biochemical attempts to define the nature of glomerular cells cultured in vitro.” National Kidney Foundation of Wisconsin, $1000, 7-1-81 to 6-30-82.
12. "Cell Biology of the Kidney.” Research and Development Committee of the Department of Pathology, $13,000, 9-1-81 to 8-30-82.
13. "Attempts at Characterization and Localization of Glomerular Stem Cells in vivo and in vitro.” UW Graduate School, $5000, 7-1-82 to 6-30-83.
14. "Role of Precursor Cells in Glomerular Cell Injury.” Dept. of Vetrans Affairs RAGS grant, $25,000, 7/83- 6/30/84.
15. "Studies on the Possible Role of Reactive Oxygen Metabolites in Allograft Rejection." National Kidney Foundation of Wisconsin, $6500, 7-1-84 to 6-30-85.
16. "Studies on the Role of Fibronectin in Kidney Cell Outgrowth in Cell Culture." UW Graduate School, $12,000, 7-1-84 to 6-30-85.
17. "Studies on Growth of Glomerular Cells in Culture." Dept. of Veterans Affairs Merit Review, $134,200, 10/84 to 9/87.
18. "Estrogen Carcinogenicity and Hormone Dependent Tumors." NIH grant, J.J. Li, Principal Investigator, T.D. Oberley, Co-Investigator, 25% effort, $1, 975,523, 3/88- 2/93, $40,000 annually to Dr. Oberley.
19. "Immunocytochemistry of Antioxidant Enzymes in DES-Induced Renal Cancer.” VA Merit Review, $198,900, 10/90 to 9/93.
20. "Histogenesis of Estrogen-Induced Renal Cancer.” UW Graduate School, $5000, 7-1-93 to 6-30-94.
21. "Superoxide Dismutase Levels in Tumor Cells.” NIH grant, LW Oberley, Principal Investigator, TD Oberley, Consultant, 0% effort, $643,000, 4-91 to 3-96, $4000 annually to Dr. TD Oberley.
22. "Suramin: A Study of Energy Balance in Prostate Cancer.” NIH grant, G Wilding, Principal Investigator, TD Oberley, Co-Investigator, 10% effort, $417,250, 7-92 to 6-95, $3000 annually to Dr. TD Oberley.
23. “Role of PKC in Tumor Promotion.” NIH grant, AK Verma, Principal Investigator, TD Oberley, Co-Investigator, 5% salary support and supplies to Dr. Oberley, 7/96-6/01.
24. EHS Center for Developmental and Molecular Toxicology grant (NIEHS Center Grant ES09090): Pilot Project: Inducible overexpression of manganese superoxide dismutase as a model for study of the effects of intracellular oxidative stress on the cell cycle, $12,000, 7-1-2000 to 6-30-2001.
25. EHS Center for Developmental and Molecular Toxicology grant (NIEHS Center Grant ES09090): as above, $3,000 for study of gene expression arrays in the above culture model.
26. “Redox Regulation of Tumor Suppression by MnSOD,” D.K. St. Clair, P.I.; T.D. Oberley, Co-I. R01-CA-73599, 7/98-6/02. $48,152/yr to Dr. Oberley.
27. “Suppression of Malignant Phenotype, Regulation of Redox-Sensitive Gene Expression and Modulation of Oxidative Damage by Overexpression of MnSOD and CuZnSOD in Human Prostate Cancer Cells,”P.I.; T Oberley, UW Department of Pathology and Laboratory Medicine, 7/99-6/02, $26,000.
28. “Oxidative Stress, Cell Cycle, and Chromosomal Ploidy.” VA Merit Review, 10/99-9/02. $75,000/yr to Dr. Oberley as PI. (bridge funding of $19,000 provided until new VA Merit funding begins 1/04 - see item #9 below)
29. NIH R01-HL-80152, “The role of MnSOD in drug resistance and cardiac toxicity,” D.K. St. Clair-PI; T.D. Oberley, Co-I (10% effort and 10% salary). 7/99 to 6/04, direct costs to Dr. Oberley in 2002 approximately $70,000.
30. Department of Defense, “Understanding molecular mechanisms of androgen-induced oxidative stress for chemoprevention of prostate cancer,” G. Wilding, PI; T.D. Oberley, Co-I (2% effort and 2% salary). 11/01/01 to 10/31/04, direct costs for this period $535, 740. Dr. Oberley had a post-doctoral fellow on this grant.
Current Research Support:
1. T32AG00213 (PI: R. Weindruch; T. Oberley, Trainer), 5/01/01-4/30/07. NIH/NIA $368, 151 (First Year-Direct); $1, 964, 679 (Total Direct), Biology of Aging and Age-Related Diseases.
2. NIH, “Mechanisms of Redox Mediated Cardioprotection,”: D.K. St. Clair, PI: T.D. Oberley, Co-I (5% effort and 5% salary). 9/01/02 to 8/31/07, direct costs for this period $1, 645, 174 (direct costs to Dr. Oberley for first year $60, 763).
3. NIH, “Oxidative Stress and Aging: Integrated Mechanisms,” K. Kregel, PI; T.D. Oberley, Co-I (5% effort and 5% salary). 09/01/02 to 08/30/07, direct costs for this period $1, 593, 899 (direct costs to Dr. Oberley for first year $70, 033).
4. NIH, “Role of PKC in Tumor Promotion,” A.K.Verma, PI; T.D.Oberley, Co-I (5% effort and 5% salary). 04/01/02 to 03/31/07, direct costs for the period $1, 250,000. Dr. Oberley has a graduate student on this grant.
5. NIH, “Redox Regulation of Tumor Suppression by MnSOD, “ Daret St. Clair, PI, T.D. Oberley, Co-I (5% effort and 5% salary), 10/01/02-9/30/07, subcontract to Dr. Oberley, direct costs of approximately $70,000/yr.
6. VA Merit Review, “Mitochondrial Redox State and Prostate Cancer, “ T.D. Oberley, PI (25% effort), $150,000/yr, (1-1-04 through 12-31-07).
7. Department of Pathology and Laboratory Medicine Research Committee, “Conversion of transmission electron microscopy (TEM imaging) from film to digital acquisition”, $32,000, 2005.
SERVICE:
University Service:
University Physicians in Pathology, 1979-96
Research and Development Committee of the Department of Pathology, 1981-83
Graduate Education Committee of the Department of Pathology, 1979-present
Scanning Electron Microscopy, 1980-83
Chairman, Pathology Department Electron Microscopy Committee, 1981-83
Faculty Senate, 1978-80
Member, Pathology Chairman Search Committee, 1982-83, 1994
House Staff Committee, 1983-present
Medical School Student Promotions Committee, 1990-97
Medical School Educational Policy Council, 1995-97
Chairman of both the Foundation Faculty Evaluation Committee and the Department Faculty Evaluation Committee, 2000-2002
Chairman of the Hematopathology Search Committee, 2000.
Pediatric Pathology Search Committee, 2000.
Pathology Compensation Plan Committee, 2000.
Chairman of the Mentoring Committee of Dr. Salamat, 1995-2000
Chairman of the Five Year Evaluation Committee of Dr. Westgard, 2000
Medical School MAMA Oversight Committee, 2001-2003
Dept. of Pathology Executive Administrative Committee, 2000-present
Member, Mentoring Committee, Andreas Friedl, 1996-2004.
Member, Jon Odorico (Surgery) Mentoring Committee, 1998-2004
Member, Will Burlingham (Surgery) Mentoring Committee , 1998-2004
Member, Mentoring Committee, Roby Rogers, 2000-2001
Member, Mentoring Committee, Michael Fritsch, 2000-present
Chairman, Five Year Evaluation Committees for Drs. Kurtycz, Gilchrist, and Chandra, 2001
Vice-Chairman, Department of Pathology and Laboratory Medicine, 1996-present
In this role, Dr. Oberley is involved in Departmental recruiting, meeting with the Chairman weekly to discuss Department administrative and policy issues, replacing the Chairman’s administrative functions in his absence, including attending a large number of academic and administrative meetings, and serving on the Department Executive Committee. The function of this latter Committee is to determine administrative policies and procedures in the Department and to implement Departmental Strategic Planning initiatives.
Member, Five Year Review Committee of Dr. Sunita Chandra, 2002
Member, Mentoring Committee, Dr. Fushen Xu, 2002
Member, Mentoring Committee, Dr. Rashmi Agni, 2002
Chairman, FiveYear Review Committee, Dr. Reza Hafez, 2002
Quality Assurance Program, renal biopsy program, 2002-present
Quality Assurance Program, autopsy pathology program, 1998-present
Director, Electron Microscopy, with annual national quality assurance program, 1983-present
Chairman, Animal Care Committee, VA Hospital, 1996-2004
Member, Research and Development Committee, VA Hospital, 1998-present
Faculty Promotions Committee, appointed by the Dean of the Medical School, 2002-2005
Chairman, Catherine Leith Mentoring Committee, 2002
Chairman, Five Year review Committee of Dr. James Malter, 2002
Chairman, Mentoring Committee, Dr. Yu, 2002
Member, Mentoring Committee, Dr. Teresa Darcy, 2002
Member, Conflict of Interest plan for Lynn Allen-Hoffmann, 2002
Summary Of administration in 2005:
Department of Pathology Faculty Recruitment Committee 2005-present
Department of Pathology Leadership Committee 2005-present
Quality Assurance Program, VA anatomic pathology 2005-present
Faculty Mentoring
Weixiong Zhong MD/PhD (Pathology) (received both NIH and VA awards this year)
Jingwei Yu PhD (Pathology)
Arjang Djamali MD (Nephrology) (received a K08 with Dr. Oberley as one mentor)
Jason Gee MD (Urology) (received VA new investigator award with Dr. Oberley as one mentor)
Catherine Leith (Pathology)
Michael Fritsch (Pathology)
Maria Alfonso-Jaume (Medicine)
Dr. Jim Li (Pathology)
Dr. Rao Adibhatla (Neurosurgery)
Public Service:
Kidney Foundation of Wisconsin, member of Executive Committee, 1980-88
Kidney Foundation of Wisconsin, member of Research Award Committee, 1982-86
Chairman, Research Committee, Kidney Foundation of Wisconsin, 1983
Clinical Service:
Kidney biopsy program director: Dr. Oberley supervises light, immunofluorescence and electron microscopy of biopsies. He is general consultant for kidney pathology in the state. When he began to work in this program, there were approximately 80 biopsies with two full-time and two part-time kidney pathologists. This year, there will be over 700 renal biopsies with three part-time kidney pathologists (Drs. Oberley, Friedl, and Zhong). The type of cases has also changed. Approximately 500 of the biopsies are kidney transplant cases. These biopsies require consultation with the transplant service, frozen section analysis, interpretation of the permanent sections, then final consultation with the transplant service. This service includes both night and weekend hours.
In general, Dr. Oberley shows completed cases to nephrology and transplant staff, residents, and medical students. This takes considerable time.
Dr.Oberley is Chief of Electron Microscopy at the VA Hospital and the Department of Pathology, University of Wisconsin Hospital. He, therefore, consults with both surgical pathology and clinical services on cases that he evaluates, often resulting in conference presentations. He presents 3 conferences per year in electron microscopy.
Because of his expertise in kidney pathology and electron microscopy, Dr. Oberley interacts with both clinical and basic science departments as much as possible; these interactions often result in multidisciplinary publications.