CURRICULUM VITAE
TERRY D. OBERLEY, MD, PhD
[Update: December 2005]
FORMAL EDUCATION AND POSITIONS HELD:
Education:
BS (Biology), from Northwestern University, Evanston, Illinois 1968
PhD (Microbiology) from Northwestern University, Evanston, Illinois 1973
Thesis Title: "The Effect of Streptolysin O on the Red Cell Membrane",
J.L. Duncan, PhD, Advisor
MD, from Northwestern University, Chicago, Illinois 1974
Postgraduate Education:
Intern in Pathology, University of Wisconsin Medical School 1974-75
USPHS Pathology Trainee, University of Wisconsin Medical School 1975-77
Resident in Pathology, University of Wisconsin Medical School 1977-78
American Cancer Society Fellow, Department of Pathology, University of Wisconsin 1977-78
Medical School
Board Certification:
American Board of Pathology (AP) 1978
Professional Appointments:
Assistant Professor, Department of Pathology, University of Wisconsin Medical School 1977-83
Associate Professor, Department of Pathology, University of Wisconsin Medical School 1983-91
Professor, Department of Pathology, University of Wisconsin Medical School 1991-present
Interim Chair, Dept. of Pathol. and Lab. Med., Univ. of Wis Medical School 1995
SPECIAL HONORS OR AWARDS:
Full academic scholarship to Northwestern University, 1964-68.
Full academic scholarship to Northwestern University Medical School, 1969
SOCIETY MEMBERSHIPS:
American Society of Investigative Pathology
American Society for Cancer Research
American Society of Nephrology
American Association for the Advancement of Science
American Society for Microbiology
American Society of Nephrology, Renal Pathology Society
Society for Free Radical Biology and Medicine
TEACHING:
Dr. Oberley has been involved in teaching medical students cell injury, renal pathology, and pathology laboratory for the past 30 years. Recently, his teaching has switched to mentoring of graduate students, postdoctoral fellows, residents, and faculty.
Classroom Teaching:
The following lectures were given in 2004-2005:
a. Pathology 703; 3 lectures
b. Renal Pathology, second year medical students, 2 lectures
c. Pathology 803, 2 lectures
d. Pathology Residents, one hour lecture on renal pathology
Mentor Teaching:
The following graduate students were trained in my laboratory:
a. Joanne Murphy-Ullrich, PhD. Dr. Murphy-Ullrich's PhD work resulted in ten refereed publications. In addition, Dr. Murphy-Ullrich and Dr. Oberley co-authored a chapter in a book (Fibronectin, edited by D.F. Mosher). She is currently an Associate Professor in the Department of Pathology at the University of Alabama at Birmingham.
b. Bruce Steinert, PhD. Dr. Steinert's PhD work resulted in five refereed publications. He is currently a Research Scientist in the Department of Surgery at Wayne State University.
c. An-Hang Yang, DDS, PhD. Dr. Yang's PhD work resulted in five refereed publications. He is currently Associate Professor of Pathology at the Medical School in Taipei, Taiwan.
d. Alfonso Gonzalez, MD, PhD. Dr. Gonzalez is currently in private clinical practice. His PhD work resulted in three refereed publications.
e. Janice Schultz, MS, PhD. Dr. Schultz’s work resulted in three published papers. She is currently raising a family.
f. Ning Li, MD, PhD. Dr. Li's work resulted in three refereed publications. She is currently a Scientist at UCLA Medical School.
g. Ted Zainal, MS, PhD. Dr. Zainal is an Assistant Professor, Dept. of Biochemistry, Winthrop College. His work resulted in four papers published.
h. Aekyong Kim, MS, PhD. is a postdoctoral fellow at Stanford University. Her work resulted in three published papers.
i. Luksana Chaiswing, MS, PhD. is working as a postdoctoral fellow in Dr. Oberley’s laboratory. Her PhD thesis work resulted in two publications as senior author and several publications as co-author.
j. Yafan Li, BS, PhD. graduated in December 2005. Her work resulted in one refereed publication with two other manuscripts submitted. She is currently looking for employment.
Other individuals trained in Dr. Oberley’s laboratory:
a. Shamila Mauyeddi, MD. Dr. Mauyeddi trained in kidney pathology in Dr. Oberley’s service. She is now Assistant Professor, Dept. of Pathology, University of Texas at Houston.
b. Andreas Friedl, MD. Dr. Friedl trained in kidney pathology in Dr. Oberley’s service. He is now Associate Professor, Dept. of Pathology, University of Wisconsin.
c. Weixiong Zhong, MD, PhD. Dr. Zhong served as a Research Fellow in Dr. Oberley’s laboratory. His work has resulted in multiple publications. Dr. Zhong also trained in kidney pathology with Dr. Oberley. He is now Assistant Professor, Dept. of Pathology, University of Wisconsin.
d. Jose Torrealba MD. Dr. Torrealba trained in kidney transplant pathology under Dr. Oberley’s supervision. His work has resulted in numerous publications, both as primary and co-author, with transplant faculty being senior authors and Dr. Oberley serving as co-author. Dr. torrealba is currently Assistant Professor, Dept of Pathology, University of Wisconsin.
d. Yung Yen Chiang, PhD. Dr. Chiang served as a postdoctoral fellow in Dr. Oberley’s laboratory. His work resulted in one publication.
e. Yi Xue, MD., PhD. Dr. Xue served as a postdoctoral fellow. His work resulted in two publications. He is now Instructor, Dept. of Neuroscience, Univ. of Tennessee Medical School.
f. Ying Zhang, PhD. served as a post-doctoral fellow in Dr. Oberley’s laboratory. Her work has resulted in one manuscript in preparation. She is currently raising a family.
g. Luksana Chaiswing, MS, Ph.D. is currently a post-doctoral fellow in Dr. Oberley’s laboratory.
h. Undergraduate students: Dr. Oberley has had many undergraduate students in his laboratory doing independent research. Ms. Jenny Ostrom received a Howard Hughes fellowship to attend any graduate program of her choice after working two years in his laboratory. Her work resulted in one publication. She received her Ph.D degree from the Department of Cellular and Molecular Biology, Washington University, St. Louis, MO.
i. High school students: Three minority students have received stipends from the Medical School for a summer research project in Dr. Oberley’s laboratory.
j. Current faculty mentoring: Dr. Oberley is currently mentoring Dr. Weixiong Zhong (has received NIH RO1 and VA Merit Review Awards), Dr. Jason Gee (has received VA Young Investigator Award with Dr. Oberley as mentor), and Dr. Ajit Djamali (has received an NIH R21 Award with Dr. Oberley as mentor).
PhD Thesis Committees in 2004
Deric Wheeler, Human Oncology (Ph.D. completed 5-2004)
Amit Dande, Pathology (M.S. degree completed 6-2004)
PhD Thesis Committees in 2005
Diantha Kelman, Environmental Toxicology
Sherly Briana Bellevue, Environmental Toxicology
Joseph Thomas Dever, Environmental Toxicology
Akua Oduro, Pathology; passed preliminary exam in November 2005.
Angela Gibson, MD/PhD student
Elyse Lee, Environmental Toxicology; Elyse graduated in December 2005.
Nadira DeAbrew, Environmental Toxicology
Yu Mu, Pathology
Marcus Calkins, Environmental Toxicology
W. Abdel Magid, Animal Sciences
Graduate Students in Dr. Oberley’s laboratory in 2005
Aekyong Kim, Environmental Toxicology; Aekyong graduated in December 2004 and remained in the lab through the end of February 2005
Jeanne Bourdeau-Heller, Pathology; Jeanne is scheduled to graduate in June 2006.
Yafan Li, Environmental Toxicology; Yafan graduated in December 2005.
Weihua Shan; Weihua worked in the summer learning techniques in Dr. Oberley', but in the fall of 2005 enrolled in the Environmental Toxicology program.
International Students in Dr. Oberley’s laboratory in 2005
Ramaneeya Nithipongvanitch; Ramaneeya is supported by a partial stipend from the government of Thailand to work on her Ph.D degree in Dr. Oberley’s laboratory.
Postdoctoral Fellow in Dr. Oberley’s laboratory in 2005
Dr. Luksana Chaiswing
International Fellow in Dr. Oberley’s laboratory in 2005
Dr. Cristiana Barbi received a followship from the Department of Pathology of the University of Bologna, Italy to pursue studies on redox and p53 in my laboratory. She began Sept 1, 2005.
Graduate student rotation in 2005
Rohinton Tarapore of Environmental Toxicology rotated through my lab in October 2005
Undergraduate students in 2005
Wade Alters (2 semesters of independent study)
David Gelbmann (research volunteer)
Resident Postgraduate Training:
Dr. Oberley has several major functions in training residents. These include supervision of pathology rotations
in kidney pathology and electron microscopy. He supervises residents in the interpretation of renal biopsies using light, immunfluorescence, and electron microscopy techniques. Residents are responsible for completing surgical pathology reports of selected cases after review with Dr. Oberley. In addition, once a week, cases from the files are reviewed to illustrate important diagnostic features of kidney pathology. Every other year, Dr. Oberley and one nephrology staff member (Dr. Moorthy), give a formal course in renal pathology for pathology residents and nephrology fellows.
The electron microscopy rotation is a unique opportunity for the residents; they are taught not only to interpret
pathology but are also encouraged to become adept at using the microscope. During the rotation, electron
microscopy cases are reviewed with the resident. Again, once a week, cases from the files are reviewed to
expand the diagnostic acumen of the trainees. Dr. Oberley presents several clinical conferences on electron
microscopy for pathology residents.
Dr. Oberley has served on the combined UW/VA Autopsy Service for two weeks, supervising residents in
gross dissection and subsequent interpretation of slides. Dr. Oberley performed this service until 2001, at which time the autopsy service was reorganized, now staffed by physicians specializing or especially interested in autopsy pathology. Dr. Oberley is available for examination of kidney autopsy slides and general electron microscopy of autopsy cases throughout the year.
Dr. Oberley encourages residents to do research in his laboratory. Dr. Ramesh Ramanathan, Dr. Alfonso
Gonzalez, Dr. Weixiong Zhong, and Dr. Jose Torrealba worked under his supervision; in each case, at least one research publication resulted.
Resident rotation in renal pathology in 2004-2005 under Dr. Oberley’s supervision:
Dr. Dong Chen
Dr. Brad Carmichael
Dr. Bob Corliss
Dr. Ching Voss
Dr. Sara Sewell
RESEARCH:
Dr. Oberley’s primary interest has been the role of oxygen radicals and antioxidant enzymes in both cell injury and carcinogenesis. He developed both tissue culture and in vivo techniques to study this problem. Dr. Oberley has made major contributions to this field of study. He has documented tissue and subcellular localization of antioxidant enzymes and oxidative damage products using well-characterized antibodies. He has demonstrated that human tumor cells have an imbalance of antioxidant enzymes. He has shown that both reactive oxygen species and antioxidant enzymes vary in specific ways in the mammalian cell cycle, suggesting a physiologic role for reactive oxygen species in the cell cycle, and a regulatory role for antioxidant enzymes during this process. His goal for the future is to use a variety of methodologies to establish a role for oxygen radicals in carcinogenesis and to document a role for antioxidant enzymes in regulation of cell cycle progression. Dr. Oberley’s research was described in a history of free radical research in the J. of NIH Research, 9:64-68, 1997, indicating his national recognition in this area. Dr. Oberley was invited to write a Commentary in the American Journal of Pathology; this overview article entitled “Oxidative damage and Cancer” appeared in the January 2002 issue ot this journal. Dr. Oberley was recently appointed for five years to the Editorial Board of Free Radical Biology and Medicine. Dr. Oberley ws named co-editor for a Forum in Antioxidant and Redox Signaling on “Redox State and Carcinogenesis.” He was recently appointed to the Editorial Board of the Biochemical Journal.
Because of his expertise in oxygen radicals, Dr. Oberley is a member of the Environmental Toxicology Program and has had three graduate students in this program. In addition, he is a member of the University of Wisconsin Comprehensive Cancer Center and was appointed to the Institute on Aging in 1997. In both 1997 and 2000, Dr. Oberley participated in completing a program project grant in molecular developmental toxicology and a successful grant application for a training program in aging.
PUBLICATIONS:
*Asterisk with italics indicates publications in which almost all work was completed in Dr. Terry Oberley’s laboratory and/or Dr. Terry Oberley is the primary or corresponding author. Dr. Oberley’s name is underlined in these primary publications.
Papers in Referreed Journals:
*1. Oberley TD, and Duncan JL: Characteristics of streptolysin O action. Infect Immun 4:683-687, 1971.
*2. Oberley TD, and Duncan JL: Streptolysin O induced alterations in rabbit erythrocyte membrane polypeptides. Biochem Biophys Res Comm 48:1339-1347, 1972.
3. Burkholder PM, Oberley TD, Barber TA, Beacom A, and Koehler C: Immune adherence in renal glomeruli: Complement receptor sites on glomerular capillary epithelial cells. Am J Path 86:635-654, 1977.
4. Barber TA, Oberley TD, and Burkholder PM: Application of correlative HVEM-SEM to the study of cultured renal glomerular cells. In: Scanning Electron Microscopy, IIT Research Institute, Chicago, Vol. II, 1977, pp. 595-602.
*5. Oberley TD, Burkholder PM, Barber TA, and Hwang CC: Cytochemical characterization of cultured adult guinea pig glomerular cells. Invest Cell Path 2:27-44, 1979.
*6. Oberley TD, Burkholder PM, and Mills MD: Culture of human glomerular cells. Am J Pathol 96:101-120, 1979.
*7. Oberley TD, Mosher DF, and Mills MD: Immunohistochemical localization of fibronectin within the renal glomerulus and its production by cultured glomerular cells. Am J Path 96:651-662, 1979.
8. Oberley LW, Oberley TD, and Buettner GR: The role of oxygen radicals and superoxide dismutases in cell differentiation, aging, and cancer. Medical Hypotheses 6:249-268, 1980.
*9. Oberley TD, Muth JV, and Murphy-Ullrich JE: Growth and maintenance of glomerular cells under defined conditions. Am J Path 101:43-51, 1980.
*10. Oberley TD, Murphy-Ullrich JE, and Muth JV: The effect of fetal calf serum on the biology of cultured glomerular cells. Diagnost Histopath 4:117-128, 1981.
11. Leuthauser SWHC, Oberley LW, Oberley TD, Sorenson JRJ, and Ramikrishna, K.: Antitumor effect of a copper coordination compound with superoxide dismutase-like activity. J Natl Cancer Inst 6:1077-1081, 1981.
*12. Oberley TD, Chung AE, Murphy-Ullrich JE, and Mosher DF: Studies on the localization of the glycoprotein GP-2 within the renal glomerulus in vivo and in cultured kidney cell strains in vitro. J Histochem Cytochem 29:1237-1242, 1981.
*13. Oberley TD, Gilbert EF, Arya S, and Viseskuhl C: Culture of human glomeruli from patients with metabolic and genetic diseases. Arch Path Lab Med 105:256-258, 1981.
14. Oberley LW, Oberley TD, and Buettner GR: Cell division in normal and transformed cells: The possible role of superoxide and hydrogen peroxide. Medical Hypotheses 7:21-42, 1981.
*15. Oberley TD, Murphy-Ullrich JE, and Muth JV: Morphologic and immunofluorescence studies on the effect of fibroblast growth factor on the culture of glomerular cell strains. Am J Path 102:129-237, 1981.
*16. Oberley TD, Murphy-Ullrich JE, and Muth JV: The growth of glomerular cells as a confluent monolayer: The effect of prostaglandins and extracellular matrix molecules. Am J Path 104:183-190, 1981.
17. Leuthauser SWC, Oberley LW, and Oberley TD: Anti-tumor activity of picolinic acid in CBA/J mice. Journal Natl Cancer Inst 68:123-126, 1982.
18. Mahler P, Oberley TD, and Yatvin M: Morphologic effects of protein restriction on the kidney following unilateral nephrectomy and radiation. Rad Res 89:546-58, 1982.
*19. Murphy-Ullrich JE, Oberley TD, and Mosher DF: Glomerular and vascular injury in mice following immunization with heterologous and autologous fibronectin. Virchows Archiv (Cell Path) 30:305-32l, 1982.
*20. Oberley TD, Murphy PJ, Steinert BW, and Albrecht RM: A morphologic and immunofluorescent analysis of primary guinea pig glomerular cell types grown in chemically defined media: Evidence for clonal growth and cell differentiation. Virchows Archiv (Cell Path) 41:145-170, 1982.
*21. Oberley TD, Murphy-Ullrich JE, Albrecht RM, and Mosher DF: The effect of the dimeric and multimeric forms of fibronectin on the adhesion and growth of primary glomerular cells. Exp Cell Res 145:265-276, 1983.
22. Glass N, Sires B, Oberley T, and Balish E: Is microbiologic flora a determinant of allograft rejection? An experimental study in gnotobiotic animals. J Surg Res 34:438-442, 1983.
23. Wilkey D, Yocum DE, Oberley TD, Karl L, and Sundstrom WR: Budd-Chiari Syndrome and renal failure in Bechet's: Report of a case and a review of the literature. Am J Med 75:541-550, 1983.
24. Zimmerman S, Dabbagh S, Oberley T, Friedman A, and Chesney R: Nephrotic syndrome in a three-year old boy. Am J Nephrol 3:286-292, 1983.
25. Sollinger HW, Starling JR, Oberley T, Glass NR, and Belzer FO: Severe "weeping" kidney after transplantation: A case report. Transplant Proc 15: 2157-160, 1983.
*26. Oberley TD, and Steinert BW: Effect of the extracellular matrix molecules fibronectin and laminin on the adhesion and growth of primary renal cortical epithelial cells. Virchows Archiv (Cell Path) 414:337-354, 1983.
27. Oberley LW, Rogers KL, Schutt L, Oberley TD, Leuthauser SWC, Sorenson JRJ: The role of glutathione in the antitumor effect of a copper-containing synthetic superoxide dismutase. Journal National Cancer Inst 71:1089-1094, 1983.
28. Friedman AL, Chesney RW, Oberley TD, and McEnery PT: Clinical systemic lupus erythematous with dense deposit disease. Internat J Ped Nephrol 4:171-175, 1983.
29. Sorenson JRJ, Oberley LW, Crouch RK, Kensler TW, Kishore V, Leuthauser SWC, Oberley TD, and Pezeshk, A.: Pharmacologic activities of copper compounds in chronic diseases. Biol Trace Element Research 5:257-273, 1983.
30. Oberley LW, Oberley TD: The role of superoxide dismutase and gene amplication in carcinogensis. J. Theoretical Biol 106:403-422, 1984.
31. Leuthauser SWC, Oberley LW, Oberley TD, and Loven DL: Lowered superoxide dismutase activity in distant organs of tumor-bearing mice. J Natl Cancer Inst 72:1065-74, 1984.
*32. Murphy-Ullrich JE, Oberley TD: Immune-mediated injury to basement membranes in mice immunized with murine laminin. Clin Immunol Immunopath 31:33-43, 1984.
*33. Murphy-Ullrich JE, Oberley TD, and Mosher DF: Detection of autoantibodies in rabbits immunized with denatured human fibronectin monomer. Am J Path 117:1-11, 1984.
34. Abreo K, Oberley TD, Gilbert EF, Opitz JM, and Updike S: Clinicopathologic Conference. A 29-year-old man with recurrent episodes of fever, abdominal pain and vomiting. Am J Med Genetics 18:249-264, 1984.
35. Yatvin MB, Oberley TD, and Mahler PA: The beneficial effect of dietary protein restriction on radiation nephropathy. Strahlentherapie 160:707-714, 1984.
*36. Oberley TD, Steinert BW, Yang AH, and Anderson PJ: Kidney glomerular explants in serum-free media: Sequential morphologic and quantitative analysis of cell outgrowths, Virchows Archiv (Cell Path.), 50:209-235, 1986.
*37. Oberley TD, Steinert BW, and Anderson PJ: Kidney glomerular explants in serum-free media: Role of individual medium components in cell outgrowth, Virchows Archiv (Cell Path.), 51:161-176, 1986.
*38. Steinert BW, Anderson PJ, Oberley LW, and Oberley TD: Kidney glomerular explants in serum-free media: Demonstration of intracellular antioxidant enzymes and active oxygen metabolites, In Vitro, 22:285-294, 1986.
39. Friedman AL, Langer, S., Oberley TD, Thornquist M: Alterations in rat renal glucose transport following in vivo use of Freund's adjuvant. Pediatr Res 20:443- 446, 1986.
*40. Oberley TD, Yang AH, and Gould-Kostka J: Selection of kidney cell types in primary glomerular explant outgrowths by in vitro culture conditions, J Cell Science 84:69-92, 1986.
*41. Murphy-Ullrich JE, Oberley TD, and Mosher DF: Serologic and pathologic studies of mice immunized with homologous fibronectin. Am J Path 125: 182-190, 1986.
42. Konick L, Hafez GR, Weiss SL, Oberley TD, Hartmann HA: Multiple myeloma with unusual intracranial manifestations. Arch Pathol Lab Med 110:755-756, 1986.
*43. Yang AH, Gould-Kostka J, Oberley TD: In vitro growth and differentiation of human kidney tubular cells on a basement membrane substrate. In Vitro 23:34-46, 1987.
44. Engstrand DW, England DE, Oberley TD: Microvillous ultrastructure in distinguishing between primary carcinoma of the lung and metastatic disease. Ultrastruct Pathol 11:53-58, 1987.
45. Oberley LW, Kasemset D, Autor AP, Oberley TD: Increase in manganese superoxide dismutase activity in the mouse heart after X-irradiation. Arch Bioch Biophys 254:69-80, 1987.
46. Reznikoff CA, Loretz LJ, Pesciotta DM, Oberley TD: Growth kinetics and differentiation in vitro of normal human uroepithelial cells in defined and serum-containing medium. J Cell Physiol 131:285-301, 1987.
47. Willson JKV, Bittner GN, Oberley TD, Meisner LF, and Weese JL: Human colon neoplastic cells in culture. Cancer Res 47:1-1, 1987.
48. Christian BJ, Loretz LJ, Oberley TD, and Reznikoff CA: Characterization of human uroepithelial cells immortalized in vitro by Simian Virus 40. Cancer Res, 47:6066-6073, 1987.
*49. Yang AH, Oberley TD, Oberley LW, Schmid SM, and Cummings KB: In vitro modulation of antioxidant enzymes in normal and malignant renal epithelium. In Vitro, 23:546-558, 1987.
50. Shorr RI, Longo WL, Oberley TD, Bozdech MJ, Walker DL: Cytomegalovirus associated tubulo-interstitial nephritis in an allogeneic bone marrow transplant recipient. Ann Int Med 107:51-52, 1987.
51. Kuebler JP, Oberley TD, Meisner LF, Sidky YA, Reznikoff CA, Borden EC, Cummings KB, Bogen GT: Effect of interferon alpha, interferon beta, and interferon gamma on the in vitro growth of human renal adenocarcinoma cells. Invest New Drugs 5:21-29, 1987.
52. Grauer GF, Culham CA, Cooley AJ, Poff BC, Oberley TD, Browfield MS, and Grieve RB: Clinicopathologic and histologic evaluation of Dirofilaria immitis-induced nephropathy in dogs. Am J Trop Med Hyg 37:588-596, 1987.
*53. Yang AH, Oberley TD, Oberley LW, Ramanathan R: Effect of cell substrate on antioxidant enzyme activities in cultured renal glomerular epithelium. Am J Path 130:616-628, 1988.
54. Pozniak MA, Kelcz F, Stratta RJ, Oberley TD: Extraneous factors affecting resistive index. Invest Radiol 23:899-904, 1988.
55. Oberley LW, Oberley TD: Role of antioxidant enzymes in cell immortalization and transformation. Mol Cell Biochem 84:147-153, 1988.
56. Grauer GR, Culham CA, Dubielzig RR, Presto SK, Oberley TD, Thomas CB, and Grieve RB: Effects of a specific thromboxane synthetase inhibitor on development of experimental Dirofilaria immitis immune complex glomerulonephritis in the dog. J Vet Int Med 2:192-200, 1988.
57. Bruyere HJ, Noonan JJ, Dong S, Oberley TD, Schmidt MJ, Gilbert EF, and Shug AL: The effects of caffeine on the ultrastructure and mitochondrial function of the embryonic chick heart. J Appl Toxicol 8:9-13, 1988.
58. Coursin DB, Cihla HP, and Oberley TD: Exacerbation of tallysomycin toxicity in rats by concurrent exposure to sublethal hyperoxia. Toxicology 55:225-237, 1989.
*59. Gonzalez A, Oberley TD, and Li JJ: Morphological and immunohistochemical studies on the estrogen-induced Syrian hamster renal tumor: Probable cell of origin. Canc Res 49:1020-1028, 1989.
*60. Oberley TD, Lauchner LJ, Pugh TD, Gonzalez A, Goldfarb S, Li SA, and Li JJ: Specific estrogen-induced cell proliferation of cultured Syrian hamster renal proximal tubular cells in serum-free chemically defined media. Proc Natl Acad Sci USA 86:2107-2111, 1989.
61. Wen SF, Friedman AL, and Oberley TD: Two case studies from a family with primary Fanconi syndrome. Amer J Kid Dis 13:240-246, 1989.
62. Oberley LW, Ridnour LA, Sierra-Rivera E, Oberley TD, and Guernsey DL: Superoxide dismutase activities of differentiating clones from an immortal cell line. J Cell Physiol 138:50-60, 1990.
63. Balish E, Filutowicz H, and Oberley TD: Correlates of cell-mediated immunity in Candida albicans-colonized gnotobiotic mice. Infect Immun 58:107-113, 1990.
64. Hopkins WJ, Reznikoff CA, Oberley TD, and Uehling DT: Adherence of uropathogenic E. coli. to differentiated human uroepithelial cells grown in vitro. J Urol 143:146-149, 1990.
*65. Oberley TD, Oberley LW, Slattery AF, Lauchner LJ, and Elwell JH: Immunohistochemical localization of antioxidant enzymes in adult Syrian hamster tissues and during kidney development. Am J Path 137:199-214, 1990.
66. Spitz DR, Elwell JH, Sun Y, Oberley LW, Oberley TD, Sullivan SJ, and Roberts RJ: Oxygen toxicity in control and H2O2-resistant Chinese hamster fibroblast cell lines. Arch Biochem Biophys 279:249-60, 1990.
*67. Oberley TD, Allen RG, Schultz, JL, and Lauchner LJ: Antioxidant enzymes and DES-induced proliferation of kidney tubular cells. Free Radic Biol and Med 10:79-83, 1991.
*68. Oberley TD, Gonzalez A, Lauchner LJ, and Li JJ: Characterization of early kidney lesions in estrogen-induced tumors in the Syrian hamster. Canc Res 51:1922-29, 1991.
69. McCormick ML, Oberley TD, Elwell JH, Oberley LW, Sun Y, and Li JJ: Superoxide dismutase and catalase levels during estrogen-induced renal tumorigenesis in the Syrian hamster. Carcinogenesis 12:977-83, 1991.
70. Chiang YY, Takebayashi S, Oberley TD: In vitro analysis of extracellular matrix production by porcine glomerular mesangial and vascular smooth muscle cells. Am J Pathol 138:1349-58, 1991.
71. Molteni KH, Oberley TD, Wolff JA, Friedman AL. Progressive renal insufficiency in methylmalonic acidemia. Pediatr Nephrol 5:323-26, 1991.
*72. Oberley TD, Oberley LW, Slattery AF, and Elwell JH: Immunohistochemical localization of glutathione-S-transferase and glutathione peroxidase in adult Syrian hamster tissues and during kidney development. Am J Path 139:355-69, 1991.
73. Schiller JH, Bittner G, Meisner LF, Oberley TD, Norback D, Schwabe M, Faltynek CR, Raab-Traub N: Establishment and characterization of an Epstein-Barr virus spontaneously transformed lymphocytic cell line derived from a hairy cell leukemia patient. Leukemia 5:399-407, 1991.
*74. Oberley TD, Slattery AF, Gonzalez A, Lauchner LJ, Li SA, and Li JJ: Comparative morphologic and immunohistochemical studies of estrogen plus alpha-napthoflavone-induced liver tumors in Syrian hamsters and rats. Am J Path 139:669-69, 1991.
75. St. Clair DK, Oberley TD, Ho YS: Overproduction of human MnSOD modulates paraquat-mediated toxicity in mammalian cells. FEBS Letters, 293:193-203, 1991.
76. Rago, R, Mitchen J, Cheng AL, Oberley T, Wilding G: Disruption of cellular energy balance by suramin in intact human prostate carcinoma cells, a likely antiproliferative mechanism. Cancer Res, 51:6629-35, 1991.
77. Deahl ST, Oberley LW, Oberley TD, Elwell JH: Immunohistochemical identification of superoxide dismutases, catalase, and glutathione-S-transferases in rat femurs. J Bone Mineral Res., 7:188-198, 1992.
78. Sullivan, SJ, Oberley TD, Roberts RJ, Spitz DR: A stable O2- resistant cell line: Role of lipid peroxidation byproducts in O2- mediated cell injury. Amer J Physiol 262: L748-L756, 1992.
79. St. Clair DK, Wan XS, Oberley TD, Muse KE, St. Clair WH: Overexpression of mitochondrial superoxide dismutase suppresses radiation-induced neoplastic transformation. Mol Carcinogen 6:238-242, 1992.
80. Wen SF, Parthasarathy R, Iliopoulos O, Oberley TD: Acute renal failure following binge drinking and nonsteroidal antiinflammatory drugs. Amer J Kid Dis 20:281-285, 1992.
81. Pozniak MA, Kelcz F, D'Alessandro A, Oberley TD, Stratta R: Sonography of renal transplants in dogs: The effect of acute tubular necrosis, cyclosporine nephrotoxicity, and acute rejection on resistive index and renal length. Amer J Radiol 158: 791-797, 1992.
82. Coursin DB, Cihla HP, Oberley TD, Oberley LW: Light and electron microscopic localization of antioxidant enzymes and isoenzymes of glutathione - S-transferase in normal rat lung. Amer J Physiol 263: L679-L691, 1992.
83. Schiller JH, Bittner G, Oberley TD, Kao C, Harris C, Meisner LF: Establishment and characterization of a SV-40 T-antigen immortalized human bronchial epithelial cell line. In Vitro Cell Devel Biol 28:461-464, 1992.
*84. Oberley TD, Coursin DB, Cihla HP, Oberley LW, El-Sayyad N, Ho YS: Immunolocalization of manganese superoxide dismutase in normal and transgenic mice expressing the human enzyme. Histochem J 25:267-279, 1993.
*85. Gonzalez A, Oberley TD, Schultz JL, Ostrom J, Li JJ: In vitro characterization of estrogen - induced Syrian hamster renal tumors: Comparison with an immortalized cell line derived from diethylstilbestrol - treated adult hamster kidney. In Vitro Cell Devel Biol 29A:562-573. 1993.
86. Sun Y, Oberley LW, Oberley TD, Elwell JH, Sierra-Rivera E: Lowered antioxidant enzymes in spontaneously transformed embryonic mouse liver cells in culture. Carcinogenesis, 14:1457-1463, 1993.
87. Kim ND, Oberley TD, Clifton KH: Primary culture of flow cytometry-sorted rat mammary epithelial cells (RMEC) subpopulations in a reconstituted basement membrane Matrigel. Exp Cell Res 209:6-20, 1993.
88. St. Clair DK, Oberley TD, Muse KE, St. Clair WH: Expression of manganese superoxide dismutase promotes cellular differentiation. Free Radic Biol Med 16:275-282, 1994.
*89. Oberley TD, Sempf JM, Oberley MJ, McCormick ML, Muse KE, Oberley LW: Immunogold analysis of antioxidant enzymes in human renal carcinoma. Virchows Archiv, 424:155-164, 1994.
*90. Oberley TD, Schultz JL, Oberley LW: In vitro modulation of antioxidant enzyme levels in normal hamster kidney and estrogen-induced hamster kidney tumor. Free Radic Biol Med 16:741-751, 1994.
*91. Muse KE, Oberley TD, Sempf JM, Oberley LW: Immunolocalization of antioxidant enzymes in adult hamster kidney. Histochem J 26:734-753, 1994.
92. Safford SE, Oberley TD, Urano M, St. Clair DK: Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. Cancer Res 54:4261-4265, 1994.
93. Hammond TG, Verroust PJ, Majewski RR, Muse KE, Oberley TD: Heavy endosomes isolated from the rat renal cortex show attributes of intermicrovillar clefts. Amer J Physiol 267:F516-F527, 1994.
94. Hammond TG, Majewski RR, Muse KE, Oberley TD, Morrissey LW: Energy transfer assays of rat renal cortical endosomal fusion: Evidence for superfusion. Amer J Physiol 267:F1021-F1033, 1994.
95. Moser R, Oberley TD, Daggett DA, Friedman AL, Johnson JA, Siegel FA: Effects of lead administration on developing rat kidney. I. Glutathione S-transferase isoenzymes. Toxicol and Applied Pharmacol 131:85-93, 1995.
*96. Oberley TD, Friedman AL, Moser R, Siegel FL: Effects of lead administration on developing rat kidney II. Functional, morphologic, and immunohistochemical studies. Toxicol and Applied Pharmacol 131:94-107, 1995.
*97. Oberley, TD, Schultz JL, Li N, Oberley LW: Antioxidant enzyme levels as a function of growth state in cell culture. Free Radical Biology and Medicine 19:53-65, 1995.
98. Li JJ, Oberley LW, St Clair DK, Ridnour LA, Oberley TD: Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene 10:1989-2000, 1995.
99. Urano M, Kuroda M, Reynolds R, Oberley TD, St. Clair DK,: Expression of manganese superoxide dismutase reduces tumor control radiation dose: Gene-radiotherapy. Cancer Research 55:2490-2493, 1995.
100. Li JJ, Li SA, Oberley TD, Parsons JA: Carcinogenic activities of various steroidal and nonsteroidal estrogens in hamster kidney: Relation to hormonal activity and cell proliferation. Cancer Research 55:4347-4351, 1995.
*101. Oberley TD, Sempf JM, Oberley LW: Immunohistochemical localization of antioxidant enzymes during hamster kidney development. Histochemical Journal 278:575-586, 1995.
*102. Oberley TD, Sempf JM, Oberley LW: Immunogold analysis of antioxidant enzymes in common renal tumors. Histology and Histopathology, 11:153-160, 1996.
*103. Coursin DB, Cihla HP, Sempf J, Oberley TD, Oberley LW: An immunohistochemical analysis of antioxidant and glutathione S-transferase enzyme levels in normal and neoplastic human lung. Histol Histopathol 11:851-860, 1996.
104. Zhong W, Oberley LW, Oberley TD, Domann FE, St. Clair DK: Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells. Cell Growth Differ 7:1175-1186, 1996.
105. Yen H-C, Oberley TD, Vichitbandha S, Ho Y-S, St. Clair DK: The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest 98:1253-1260, 1996.
106. Yoshida T, Watanabe M, Engelman DT, Engelman RM, Schley J, Maulik N, Ho Y-S, Oberley TD, Das DK: Transgenic mice overexpressing glutathione perioxidase are resistant to myocardial ischemia reperfusion injury. J Cell Mol Cardiol 28:1759-1767, 1996.
107. Chen C-W, Palangat M, Oberley TD, Roy D: Mechanism of antiproliferative activity of luteolin against stilbene-estrogen stimulation of hamster renal epithelial cells. Int J Oncol 9:811-814, 1996.
108. Mitchen J, Oberley TD, Wilding G: Extended culturing of androgen responsive human primary epithelial prostate cell isolates by continuous treatment with interstitial collagenase. Prostate 30:7-19, 1997.
109. Chen C-W, Oberley TD, Roy D: Inhibition of stilbene estrogen-induced cell proliferation of renal epithelial cells through the modulation of insulin-like growth factor-1 receptor expression. Cancer Lett 105:51-59, 1996.
110. Zhong W, Oberley LW, Oberley TD, St Clair DK: Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene 14:481-490, 1997.
111. Suzuki K, Oberley TD, Pugh TD, Sempf JM, Weindruch R: Caloric restriction diminishes the age-associated loss of immunoreactive catalase in rat prostate. Prostate 33:256-263, 1997.
*112. Oberley TD, Oberley LW: Antioxidant enzymes and cancer. Histol Histopathol 12:525-535, 1997.
113. Liu R, Oberley TD, Oberley LW: Transfection and expression of MnSOD cDNA decreases tumor malignancy of human oral squamous carcinoma SCC-25 cells. Human Gene Therapy 8:585-595, 1997.
114. Armstrong N, Buckley P, Oberley T, Fechner Jr. J, Dong Y, Hong X, Kirk A. Neville Jr.D, Knechtle S. Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9. Transplantation 66: 5-13, 1998.
115. Browne KE, Kinter MT, Oberley TD, Freeman ML, Frierson HF, Ridnour LA, Tao Y, Oberley LW, Spitz DR: Stimulation of gammaglutamyl transpeptidase gene expression and oxidative damage in an animal model of hemochromatosis: A potential adaptive response. Free Radical Biol Med 24:545-555, 1998.
116. Knechtle SJ, Fechner JJ, Dong Y, Stavrou S, Neville Jr.DM, Oberley T, Buckley P, Armstrong N, Rusterholz K, Hong X, Tsuchida M, Hamawy MM.. Primate renal transplants using immunotoxin. Surgery 124: 438-446, 1998.
*117. Li N, Oberley TD, Oberley LW, Zhong W: Overexpression of manganese superoxide dismutase in DU 145 human prostate carcinoma cells has multiple effects on cell phenotype. The Prostate 35:221-233, 1998.
*118. Li N, Oberley TD, Oberley LW, Zhong W: Inhibition of cell growth in NIH3T3 fibroblasts by overexpression of manganese superoxide dismutase: Mechanistic studies. J. Cell. Physiol. 175;359-367, 1998.
119. Liu R, Oberley TD, Oberley LW: The effects of expression of nitric oxide synthetase gene on tumor biology of human oral carcinoma SCC-25 cells. Cell Growth and Diff. 9:239-246, 1998.
120. Majima H, Oberley TD, Furukama K, Mattson MP, Yen H-C, St. Clair DK: Prevention of mitochondrial injury by manganese superoxide dismutase: A primary mechanism for alkaline-induced cell death. J. Biol. Chem 273:8217-8224, 1998.
121. Daggett DA, Oberley TD, Nelson SA, Wright LS, Kornguth SE, Siegel FL: Effects of lead in rat kidney and liver: GST overexpression and oxidative stress, Toxicology, 128:191-206, 1998.
*122. Li N, Oberley TD: Modulation of antioxidant enzymes, reactive oxygen species, and glutathione levels in manganese superoxide dismutase-overexpressing NIH/3T3 fibroblasts during the cell cycle. J Cell Physiol 177: 148-160, 1998.
123. Wright LS, Kornguth SE, Oberley TD, Siegel FL: Effects of lead on glutathione s-transferase expression in rat kidney: A dose-response study. Toxicol Sciences, 46:254-259, 1998.
124. Klivenyl P, St. Clair D, Wermer M, Yen H-C, Oberley T, Yang L, Beal MF: Manganese superoxide dismutase overexpression attenuates MPTP Toxicity, Neurobiology of Dis, 5:253-258, 1998
125. Yen H-C, Oberley TD, Gairola CG, Szweda LI, St. Clair DK. Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice. Arch Biochem Biophys 362: 59-66, 1999.
126. Thongphasuk J, Oberley L.W, Oberley TD, Martin SM. Induction of superoxide dismutase and cytotoxicity by manganese in human breast cancer cells. Arch Biochem Biophys 365: 317-327, 1999.
*127. Zainal TA, Weindruch R, Szweda LI, Oberley TD. Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload. Free Radic Biol Med 26: 1181-1193, 1999.
128. Pugh TD, Oberley TD, Weindruch R. Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res 59: 1642-1648 1999.
*129. Li N, Zhai Y, Oberley TD. Two distinct mechanisms for inhibition of cell growth in human prostate carcinoma cells with antioxidant enzyme imbalance. Free Radic Biol Med 26: 1154-1568, 1999.
130. Hall DM, Baumgardner KR, Oberley TD, Gisolfi CV. Splanchnic tissues undergo hypoxic stress during whole body hyperthermia. Am J Physiol 276: G1195-G1203, 1999.
131. Ripple MO, Hagopian K, Oberley TD, Schatten H, Weindruch R. Androgen-induced oxidative stress in human LNCAP prostate cancer cells is associated with mitochondrial modifications. Antioxidants and Redox Signaling 1: 71-81, 1999.
*132. Oberley TD, Toyokuni S, Szweda L. Localization of hydroxynonenal protein adducts in normal human kidney and selected human kidney cancers. Free Radic Biol Med 27: 695-703,1999.
133. Kiningham KK, Oberley TD, Lin S-M, Mattingly CA, St. Clair DK. Overexpression of manganese superoxide dismutase (MnSOD) protects against mitochondrial-initiated poly (ADP-ribose) polymerase-mediated cell death. FASEB J 13: 1601-1610, 1999.
134. Wenk J, Brennelsen P, Wlaschek M, Poswig A, Bririba K, Oberley T, Scharffetter-Kochanek K. Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the AP-1 mediated induction of matrix-metalloprotease-1 (MMP-1). J Biol Chem 274: 25869-25876, 1999.
135. Kim ND, Oberley TD, Yasukawa-Barnes J, Clifton KH. Persistence of stem-like cells in clonal glandular structures in mammary cell grafts. Exp. Cell Res 260:146-159, 2000.
136. Lam EWN, Hammad HM, Zwacka R, Darby CJ, Baumgardner KR, Davidson BL, Oberley TD, Engelhardt JJ, Oberley LW. Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumors. J Dent. Res 79:1410-1717, 2000.
137. Lagoo A, Buckley PJ, Burchell LJ, Fechner J, Tsuchida M, Dong Y, Hong X, Brunner K, Oberley TD, Knechtle S. Increased glomerular deposits of von Willenbrand factor in chronic, but not acute, rejection of primate renal allografts. Transplantation 70:877-886, 2000.
138. Chen Z, Oberley TD, Ho Y-H, Chua CC, Siu B, Hamdy RC, Epstein C.J, Chua BL. Overexpression of CuZnSOD in coronary endothelium attenuates myocardial ischemia/reperfusion injury. Free Rad Biol Med 29:589-596, 2000.
139. Reddig PJ, Dreckschmidt NE, Ahrens H, Simsiman R, Tseng C.-P, Zou J, Oberley T.D, Verma AK. Transgenic mice overexpressing protein kinase Cδ in the epidermis are resistant to skin tumor promotion by 12-0-tetradecanoyl-13-acetate. Cancer Research 59: 5710-5718, 1999.
140. Hall DM, Oberley TD, Moseley PM, Oberley LW, Weindruch R, Kregel KC. Caloric restriction improves thermotolerance and reduces hyperthermia-induced cellular damage in old rats. FASEB J 14: 78-86, 2000.
141. Zhang HJ, Yan T, Oberley TD, Oberley LW. Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype. Cancer Res 59: 6276-6283, 1999.
142. Hall DM, Xu L, Drake V, Oberley LW, Oberley TD, Moseley PL, Kregel KC. Aging reduces adaptive capacity and stress protein expression in the liver after heat stress. J Applied Physiol 89: 749-759, 2000.
143. Reddig PJ, Dreckschmidt, NE, Zou J, Bourguignon SE, Oberley TD, Verma AK. Transgenic mice overexpressing protein kinase Cε in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. Cancer Res. 60: 595-602, 2000.
*144. Zainal TA, Oberley TD, Allison DB, Szweda L.I, Weindruch R. Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J 14: 1825-1836, 2000.
*145. Oberley TD, Zhong W, Szweda LI, Oberley LW. Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium. Prostate 44: 144-155, 2000.
*146. Oberley TD, Zainal TA. Morphologic assessment of oxidative damage: a review. Age 23:17-24, 2000.
147. Becker BN, Jacobson LM, Becker YT, Radke NA, Heisey DM, Oberley TD, Pirsch JD, Sollinger HW, Brazy PC, Kirk AD. Renin-angiotensin system gene expression in post-transplant hypertension predicts allograft function. Transplantation 69: 1485-1491